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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.49

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.49

Enzymes and Genes:
glucose 6-phosphate-1-dehydrogenase Inferred from experiment : zwf ( Escherichia coli K-12 substr. MG1655 )
glucose-6-phosphate 1-dehydrogenase Traceable author statement to experimental support : G6PD ( Homo sapiens )
glucose-6-phosphate dehydrogenase Inferred from experiment : ZWF1 ( Saccharomyces cerevisiae )
glucose-6-phosphate 1-dehydrogenase Inferred from experiment : zwf ( Leuconostoc mesenteroides )
glucose-6-phosphate dehydrogenase Inferred from experiment : zwf ( Methylobacillus flagellatus )

In Pathway: superpathway of glycolysis and Entner-Doudoroff , heterolactic fermentation , formaldehyde oxidation I , pentose phosphate pathway (oxidative branch) I , NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) , pentose phosphate pathway (oxidative branch) II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
D-glucopyranose 6-phosphate + NAD(P)+ = 6-phospho D-glucono-1,5-lactone + NAD(P)H + H+ (1.1.1.363)

Enzyme Commission Primary Name: glucose-6-phosphate dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-glucose-6-phosphate dehydrogenase, Zwischenferment, D-glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), NADP-dependent glucose 6-phosphate dehydrogenase, 6-phosphoglucose dehydrogenase, Entner-Doudoroff enzyme, glucose-6-phosphate 1-dehydrogenase, G6PDH, GPD, glucose-6-phosphate dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.9264526 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+].

Citations: [Miclet01, Noltmann61, Olavarria12, Glaser55, Engel69, Julian61, Hansen02a, Ibraheem05, Iyer02, Cho90]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02736 , Rhea:15841

Relationship Links: BRENDA:EC:1.1.1.49 , ENZYME:EC:1.1.1.49 , IUBMB-ExplorEnz:EC:1.1.1.49 , UniProt:RELATED-TO:O22404 , UniProt:RELATED-TO:O22405 , UniProt:RELATED-TO:O22406 , UniProt:RELATED-TO:O24357 , UniProt:RELATED-TO:O24358 , UniProt:RELATED-TO:O24359 , UniProt:RELATED-TO:O25730 , UniProt:RELATED-TO:O51240 , UniProt:RELATED-TO:O51581 , UniProt:RELATED-TO:O65856 , UniProt:RELATED-TO:O66787 , UniProt:RELATED-TO:O81978 , UniProt:RELATED-TO:P05370 , UniProt:RELATED-TO:P0AC53 , UniProt:RELATED-TO:P11410 , UniProt:RELATED-TO:P11411 , UniProt:RELATED-TO:P11412 , UniProt:RELATED-TO:P11413 , UniProt:RELATED-TO:P12646 , UniProt:RELATED-TO:P21907 , UniProt:RELATED-TO:P29686 , UniProt:RELATED-TO:P37830 , UniProt:RELATED-TO:P37986 , UniProt:RELATED-TO:P44311 , UniProt:RELATED-TO:P48826 , UniProt:RELATED-TO:P48828 , UniProt:RELATED-TO:P54547 , UniProt:RELATED-TO:P54996 , UniProt:RELATED-TO:P56110 , UniProt:RELATED-TO:P73411 , UniProt:RELATED-TO:Q8IKU0 , UniProt:RELATED-TO:Q8L743 , UniProt:RELATED-TO:Q9FJI5 , UniProt:RELATED-TO:Q9FY99 , UniProt:RELATED-TO:Q9JTW0 , UniProt:RELATED-TO:Q9LK23 , UniProt:RELATED-TO:Q9R5T2 , UniProt:RELATED-TO:Q00612 , UniProt:RELATED-TO:Q27741 , UniProt:RELATED-TO:Q42919 , UniProt:RELATED-TO:Q43793 , UniProt:RELATED-TO:Q43839 , UniProt:RELATED-TO:Q49700


References

Cho90: Cho SW, Joshi JG (1990). "Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain." Neuroscience 38(3);819-28. PMID: 2270145

Engel69: Engel HJ, Domschke W, Alberti M, Domagk GF (1969). "Protein structure and enzymatic activity. II. Purification and properties of a crystalline glucose-6-phosphate dehydrogenase from Candida utilis." Biochim Biophys Acta 191(3);509-16. PMID: 5363983

Glaser55: Glaser L, Brown DH (1955). "Purification and properties of d-glucose-6-phosphate dehydrogenase." J Biol Chem 216(1);67-79. PMID: 13252007

Hansen02a: Hansen T, Schlichting B, Schonheit P (2002). "Glucose-6-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: expression of the g6pd gene and characterization of an extremely thermophilic enzyme." FEMS Microbiol Lett 216(2);249-53. PMID: 12435510

Ibraheem05: Ibraheem O, Adewale IO, Afolayan A (2005). "Purification and properties of glucose 6-phosphate dehydrogenase from Aspergillus aculeatus." J Biochem Mol Biol 38(5);584-90. PMID: 16202239

Iyer02: Iyer RB, Wang J, Bachas LG (2002). "Cloning, expression, and characterization of the gsdA gene encoding thermophilic glucose-6-phosphate dehydrogenase from Aquifex aeolicus." Extremophiles 6(4);283-9. PMID: 12215813

Julian61: Julian GR, Wolfe RG, Reithel FJ (1961). "The enzymes of mammary gland. II. The preparation of glucose 6-phosphate dehydrogenase." J Biol Chem 236;754-8. PMID: 13790996

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miclet01: Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F (2001). "NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase." J Biol Chem 276(37);34840-6. PMID: 11457850

Noltmann61: Noltmann EA, Gubler CJ, Kuby SA (1961). "Glucose 6-phosphate dehydrogenase (Zwischenferment). I. Isolation of the crystalline enzyme from yeast." J Biol Chem 236;1225-30. PMID: 13729473

Olavarria12: Olavarria K, Valdes D, Cabrera R (2012). "The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli--modeling the physiological production of reduced cofactors." FEBS J 279(13);2296-309. PMID: 22519976


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14A.