|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
|Aggregatibacter actinomycetemcomitans :||GDP-4-keto-6-deoxy-D-mannose reductase
In Pathway: GDP-6-deoxy-D-talose biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name for 18.104.22.168: GDP-6-deoxy-D-talose 4-dehydrogenase
Enzyme Commission Synonyms for 22.214.171.124: guanosine diphospho-6-deoxy-D-talose dehydrogenase, GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase
Enzyme Commission Primary Name for 126.96.36.199: GDP-4-dehydro-D-rhamnose reductase
Enzyme Commission Synonyms for 188.8.131.52: GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase, GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -10.649292 [Latendresse13]
Enzyme Commission Summary for 184.108.40.206:
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 220.127.116.111, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 18.104.22.168, GDP-6-deoxy-D-talose 4-dehydrogenase.
Unification Links: KEGG:R03398
Relationship Links: BRENDA:EC:22.214.171.124 , BRENDA:EC:126.96.36.199 , ENZYME:EC:188.8.131.52 , ENZYME:EC:184.108.40.206 , IUBMB-ExplorEnz:EC:220.127.116.11 , IUBMB-ExplorEnz:EC:18.104.22.168 , Rhea:RELATED-TO:10727 , Rhea:RELATED-TO:10731
Markovitz64: Markovitz A (1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose." J Biol Chem 239;2091-8. PMID: 14209931
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