twitter

MetaCyc Reaction: 1.1.1.135/1.1.1.187

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.135 , 1.1.1.187

Enzymes and Genes:

Aggregatibacter actinomycetemcomitans : GDP-4-keto-6-deoxy-D-mannose reductase Inferred from experiment : tld

In Pathway: GDP-6-deoxy-D-talose biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name for 1.1.1.135: GDP-6-deoxy-D-talose 4-dehydrogenase

Enzyme Commission Synonyms for 1.1.1.135: guanosine diphospho-6-deoxy-D-talose dehydrogenase, GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase

Enzyme Commission Primary Name for 1.1.1.187: GDP-4-dehydro-D-rhamnose reductase

Enzyme Commission Synonyms for 1.1.1.187: GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase, GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.649292 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for 1.1.1.187:
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.

Citations: [Markovitz64, Barber68, Winkler71]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03398

Relationship Links: BRENDA:EC:1.1.1.135 , BRENDA:EC:1.1.1.187 , ENZYME:EC:1.1.1.135 , ENZYME:EC:1.1.1.187 , IUBMB-ExplorEnz:EC:1.1.1.135 , IUBMB-ExplorEnz:EC:1.1.1.187 , Rhea:RELATED-TO:10727 , Rhea:RELATED-TO:10731


References

Barber68: Barber GA (1968). "The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant." Biochim Biophys Acta 165(1);68-75. PMID: 4386238

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Markovitz64: Markovitz A (1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose." J Biol Chem 239;2091-8. PMID: 14209931

Winkler71: Winkler NW, Markovitz A (1971). "Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme." J Biol Chem 246(19);5868-76. PMID: 4398966


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed May 27, 2015, biocyc14.