Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.135/1.1.1.187

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.135 , 1.1.1.187

Enzymes and Genes:
GDP-4-keto-6-deoxy-D-mannose reductase Inferred from experiment : tld ( Aggregatibacter actinomycetemcomitans )

In Pathway: GDP-6-deoxy-D-talose biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name for 1.1.1.135: GDP-6-deoxy-D-talose 4-dehydrogenase

Enzyme Commission Synonyms for 1.1.1.135: guanosine diphospho-6-deoxy-D-talose dehydrogenase, GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase

Enzyme Commission Primary Name for 1.1.1.187: GDP-4-dehydro-D-rhamnose reductase

Enzyme Commission Synonyms for 1.1.1.187: GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase, GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.649292 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for 1.1.1.187:
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.

Citations: [Markovitz64a, Barber68, Winkler71]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03398

Relationship Links: BRENDA:EC:1.1.1.135 , BRENDA:EC:1.1.1.187 , ENZYME:EC:1.1.1.135 , ENZYME:EC:1.1.1.187 , IUBMB-ExplorEnz:EC:1.1.1.135 , IUBMB-ExplorEnz:EC:1.1.1.187 , Rhea:RELATED-TO:10727 , Rhea:RELATED-TO:10731


References

Barber68: Barber GA (1968). "The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant." Biochim Biophys Acta 165(1);68-75. PMID: 4386238

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Markovitz64a: Markovitz A (1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose." J Biol Chem 239;2091-8. PMID: 14209931

Winkler71: Winkler NW, Markovitz A (1971). "Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme." J Biol Chem 246(19);5868-76. PMID: 4398966


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, biocyc13.