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MetaCyc Reaction: 1.1.1.187

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.1.1.187

Enzymes and Genes:

Aggregatibacter actinomycetemcomitans: GDP-4-keto-6-deoxy-D-mannose reductaseInferred from experiment: tld

In Pathway: GDP-6-deoxy-D-talose biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: GDP-4-dehydro-D-rhamnose reductase

Enzyme Commission Synonyms: GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-D-rhamnose reductase, guanosine diphosphate-4-keto-D-rhamnose reductase, GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase, GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.649292Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.

Citations: [Barber68, Winkler71 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03398

Relationship Links: BRENDA:EC:1.1.1.187, ENZYME:EC:1.1.1.187, IUBMB-ExplorEnz:EC:1.1.1.187, Rhea:RELATED-TO:10727, Rhea:RELATED-TO:10731


References

Barber68: Barber GA (1968). "The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant." Biochim Biophys Acta 165(1);68-75. PMID: 4386238

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Winkler71: Winkler NW, Markovitz A (1971). "Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme." J Biol Chem 246(19);5868-76. PMID: 4398966


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 13, 2016, biocyc14.