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MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

Enzymes and Genes:

Arabidopsis thaliana col: glycine decarboxylaseInferred from experimentInferred by computational analysis: AT2G35120
glycine decarboxylaseInferred from experiment: AT2G35370
Escherichia coli K-12 substr. MG1655: glycine cleavage systemInferred from experiment: lpd, gcvP, gcvH, gcvT
Gallus gallus: glycine cleavage complexInferred from experiment: GLDC, AMT, GCSH, DLD

In Pathway: folate transformations II, folate transformations I, N10-formyl-tetrahydrofolate biosynthesis, photorespiration

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Sub-reactions:
glycine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + H+ ↔ a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2,
a [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate ↔ a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + a 5,10-methylene-tetrahydrofolate + ammonium,
a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + NADH + H+

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.29180908Inferred by computational analysis [Latendresse13]

Summary:
Degradation of glycine to ammonia, CO2 and a C1 unit.

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01221, Rhea:27758

Credits:
Created 11-Sep-2014 by Caspi R, SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Feb 10, 2016, BIOCYC11A.