Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.2.1.12

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.12

Enzymes and Genes:
glyceraldehyde 3-phosphate dehydrogenase Inferred from experiment : gapA ( Escherichia coli K-12 substr. MG1655 )
testis-specific glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : GAPDHS ( Homo sapiens )
glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : GAPDH ( Homo sapiens )
glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : gap ( Bacillus coagulans )
glyceraldehyde-3-phosphate dehydrogenase : GPD ( Ogataea angusta )
NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : gapC ( Streptococcus mutans )
glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : gap ( Lactobacillus delbrueckii bulgaricus )
chloroplastic glyceraldehyde 3-phosphate dehydrogenase Inferred from experiment : GapA-1 ( Arabidopsis thaliana col )
glyceraldehyde 3-phosphate dehydrogenase Inferred from experiment : GAPC ( Solanum tuberosum )
glyceraldehyde 3-phosphate dehydrogenase Inferred from experiment ( Haloarcula vallismortis )
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : GapCp1 ( Pinus sylvestris )
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment ( Glycine max )
glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : gapA ( Mycoplasma pneumoniae M129 )
glyceraldehyde-3-phosphate dehydrogenase Inferred from experiment : gap ( Thermotoga maritima )
glyceraldehyde 3-phosphate dehydrogenase 2 : gap2 ( Synechocystis sp. PCC 6803 )

In Pathway: glycolysis IV (plant cytosol) , heterolactic fermentation , Bifidobacterium shunt , formaldehyde assimilation III (dihydroxyacetone cycle) , gluconeogenesis I , gluconeogenesis III , superpathway of glucose and xylose degradation , sucrose biosynthesis I (from photosynthesis) , glycolysis VI (metazoan) , glycerol degradation to butanol , glycolysis III (from glucose) , glycolysis II (from fructose 6-phosphate) , glycolysis I (from glucose 6-phosphate)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
D-glyceraldehyde 3-phosphate + NAD(P)+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NAD(P)H + H+ (1.2.1.59)

Enzyme Commission Primary Name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

Enzyme Commission Synonyms: triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, glyceraldehyde-3-P-dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.19458 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.

Citations: [CORI48, HAGEMAN55]

Gene-Reaction Schematic: ?

Instance reactions of [D-glyceraldehyde 3-phosphate + NAD(P)+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NAD(P)H + H+] (1.2.1.59):
i1: D-glyceraldehyde 3-phosphate + NADP+ + phosphate ← 1,3-bisphospho-D-glycerate + NADPH + H+ (1.2.1.13)

i2: D-glyceraldehyde 3-phosphate + NAD+ + phosphate ↔ 1,3-bisphospho-D-glycerate + NADH + H+ (1.2.1.12)

Unification Links: KEGG:R01061 , Rhea:10300

Relationship Links: BRENDA:EC:1.2.1.12 , ENZYME:EC:1.2.1.12 , IUBMB-ExplorEnz:EC:1.2.1.12 , UniProt:RELATED-TO:O04106 , UniProt:RELATED-TO:O25902 , UniProt:RELATED-TO:O32755 , UniProt:RELATED-TO:O34425 , UniProt:RELATED-TO:O49222 , UniProt:RELATED-TO:O59841 , UniProt:RELATED-TO:O67161 , UniProt:RELATED-TO:O68075 , UniProt:RELATED-TO:O83816 , UniProt:RELATED-TO:P00356 , UniProt:RELATED-TO:P00357 , UniProt:RELATED-TO:P00358 , UniProt:RELATED-TO:P00359 , UniProt:RELATED-TO:P00360 , UniProt:RELATED-TO:P00361 , UniProt:RELATED-TO:P00362 , UniProt:RELATED-TO:P04406 , UniProt:RELATED-TO:P04796 , UniProt:RELATED-TO:P04797 , UniProt:RELATED-TO:P04970 , UniProt:RELATED-TO:P07486 , UniProt:RELATED-TO:P07487 , UniProt:RELATED-TO:P08439 , UniProt:RELATED-TO:P08477 , UniProt:RELATED-TO:P08735 , UniProt:RELATED-TO:P09124 , UniProt:RELATED-TO:P09316 , UniProt:RELATED-TO:P09317 , UniProt:RELATED-TO:P0A9B2 , UniProt:RELATED-TO:P0A9B6 , UniProt:RELATED-TO:P10097 , UniProt:RELATED-TO:P10618 , UniProt:RELATED-TO:P16858 , UniProt:RELATED-TO:P17244 , UniProt:RELATED-TO:P17329 , UniProt:RELATED-TO:P17330 , UniProt:RELATED-TO:P17331 , UniProt:RELATED-TO:P17721 , UniProt:RELATED-TO:P17729 , UniProt:RELATED-TO:P17819 , UniProt:RELATED-TO:P17878 , UniProt:RELATED-TO:P19089 , UniProt:RELATED-TO:P20287 , UniProt:RELATED-TO:P20445 , UniProt:RELATED-TO:P22512 , UniProt:RELATED-TO:P22513 , UniProt:RELATED-TO:P23722 , UniProt:RELATED-TO:P24746 , UniProt:RELATED-TO:P24748 , UniProt:RELATED-TO:P24749 , UniProt:RELATED-TO:P24750 , UniProt:RELATED-TO:P24751 , UniProt:RELATED-TO:P25858 , UniProt:RELATED-TO:P25861 , UniProt:RELATED-TO:P26517 , UniProt:RELATED-TO:P26518 , UniProt:RELATED-TO:P26519 , UniProt:RELATED-TO:P26520 , UniProt:RELATED-TO:P26521 , UniProt:RELATED-TO:P26988 , UniProt:RELATED-TO:P28844 , UniProt:RELATED-TO:P29272 , UniProt:RELATED-TO:P29497 , UniProt:RELATED-TO:P32635 , UniProt:RELATED-TO:P32636 , UniProt:RELATED-TO:P32637 , UniProt:RELATED-TO:P32638 , UniProt:RELATED-TO:P32809 , UniProt:RELATED-TO:P32810 , UniProt:RELATED-TO:P34783 , UniProt:RELATED-TO:P34917 , UniProt:RELATED-TO:P34918 , UniProt:RELATED-TO:P34920 , UniProt:RELATED-TO:P34922 , UniProt:RELATED-TO:P34924 , UniProt:RELATED-TO:P35143 , UniProt:RELATED-TO:P39460 , UniProt:RELATED-TO:P44304 , UniProt:RELATED-TO:P46406 , UniProt:RELATED-TO:P46713 , UniProt:RELATED-TO:P46795 , UniProt:RELATED-TO:P47543 , UniProt:RELATED-TO:P49644 , UniProt:RELATED-TO:P50321 , UniProt:RELATED-TO:P50322 , UniProt:RELATED-TO:P54118 , UniProt:RELATED-TO:P54270 , UniProt:RELATED-TO:P55971 , UniProt:RELATED-TO:P64178 , UniProt:RELATED-TO:P75358 , UniProt:RELATED-TO:P78958 , UniProt:RELATED-TO:P80534 , UniProt:RELATED-TO:Q7LZR1 , UniProt:RELATED-TO:Q7M2K2 , UniProt:RELATED-TO:Q7M187 , UniProt:RELATED-TO:Q7M188 , UniProt:RELATED-TO:Q7M516 , UniProt:RELATED-TO:Q7M517 , UniProt:RELATED-TO:Q9JWT8 , UniProt:RELATED-TO:Q9JX51 , UniProt:RELATED-TO:Q9UW96 , UniProt:RELATED-TO:Q00584 , UniProt:RELATED-TO:Q01077 , UniProt:RELATED-TO:Q01558 , UniProt:RELATED-TO:Q01597 , UniProt:RELATED-TO:Q01651 , UniProt:RELATED-TO:Q07234 , UniProt:RELATED-TO:Q08060 , UniProt:RELATED-TO:Q09054 , UniProt:RELATED-TO:Q27820 , UniProt:RELATED-TO:Q27890 , UniProt:RELATED-TO:Q37264 , UniProt:RELATED-TO:Q37265 , UniProt:RELATED-TO:Q42671 , UniProt:RELATED-TO:Q43247 , UniProt:RELATED-TO:Q43359 , UniProt:RELATED-TO:Q43833 , UniProt:RELATED-TO:Q46450 , UniProt:RELATED-TO:Q48335 , UniProt:RELATED-TO:Q58546 , UniProt:RELATED-TO:Q59309 , UniProt:RELATED-TO:Q59800 , UniProt:RELATED-TO:Q59906 , UniProt:RELATED-TO:Q60143 , UniProt:RELATED-TO:Q64467


References

CORI48: CORI GT, SLEIN MW, CORI CF (1948). "Crystalline d-glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle." J Biol Chem 173(2);605-18. PMID: 18910716

HAGEMAN55: HAGEMAN RH, ARNON DI (1955). "The isolation of triosephosphate dehydrogenase from pea seeds." Arch Biochem Biophys 55(1);162-8. PMID: 14362612

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.