MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col:
Aspergillus stellatus: stellata-2,6,19-triene synthaseInferred from experiment: Stl-SS
Capsicum annuum: farnesyl diphosphate synthaseInferred from experiment: GGPPS
Diaporthe amygdali: phomopsene synthaseInferred from experiment: PS
Escherichia coli K-12 substr. MG1655: farnesyl diphosphate synthaseInferred from experiment: ispA
Ginkgo biloba: ω,E,E-farnesyl diphosphate synthaseInferred from experiment: FPS
Hevea brasiliensis: farnesyl diphosphate synthaseInferred from experiment: hbgg
Homo sapiens:
Methanothermobacter marburgensis Marburg: short chain isoprenyl diphosphate synthaseInferred from experiment: idsA
Mycobacterium tuberculosis H37Rv: ω,E,E-farnesyl diphosphate synthaseInferred from experiment: Rv3398c
Saccharomyces cerevisiae: farnesyl diphosphate synthaseInferred from experiment: FPP1
Solanum lycopersicum: farnesyl diphosphate synthaseInferred from experiment: LeFPS1

In Pathway: bisabolene biosynthesis, all-trans-farnesol biosynthesis, trans, trans-farnesyl diphosphate biosynthesis, methyl phomopsenoate biosynthesis, stellatic acid biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (2E,6E)-farnesyl diphosphate synthase

Enzyme Commission Synonyms: farnesyl-diphosphate synthase, geranyl transferase I, prenyltransferase, farnesyl pyrophosphate synthetase, farnesylpyrophosphate synthetase, geranyltranstransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.0Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.

Citations: [Ogura68, Reed75, Takahashi81, Takahashi82a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02003, Rhea:19361

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O04882, UniProt:RELATED-TO:O14230, UniProt:RELATED-TO:O24241, UniProt:RELATED-TO:O24242, UniProt:RELATED-TO:O65004, UniProt:RELATED-TO:P05369, UniProt:RELATED-TO:P08524, UniProt:RELATED-TO:P14324, UniProt:RELATED-TO:P22939, UniProt:RELATED-TO:P45204, UniProt:RELATED-TO:P49349, UniProt:RELATED-TO:P49350, UniProt:RELATED-TO:P49351, UniProt:RELATED-TO:P49352, UniProt:RELATED-TO:P49353, UniProt:RELATED-TO:Q8L7F4, UniProt:RELATED-TO:Q92218, UniProt:RELATED-TO:Q92235, UniProt:RELATED-TO:Q92250, UniProt:RELATED-TO:Q92334, UniProt:RELATED-TO:Q9CH81, UniProt:RELATED-TO:Q9JSM0, UniProt:RELATED-TO:Q9PM32, UniProt:RELATED-TO:Q08291, UniProt:RELATED-TO:Q09152, UniProt:RELATED-TO:Q43315

Revised 22-Oct-2010 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ogura68: Ogura K, Nishino T, Seto S (1968). "The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties." J Biochem 64(2);197-203. PMID: 4303505

Reed75: Reed BC, Rilling HC (1975). "Crystallization and partial characterization of prenyltransferase from avian liver." Biochemistry 14(1);50-4. PMID: 1109590

Takahashi81: Takahashi I, Ogura K (1981). "Farnesyl pyrophosphate synthetase from Bacillus subtilis." J Biochem 89(5);1581-7. PMID: 6792191

Takahashi82a: Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sat Nov 28, 2015, BIOCYC13A.