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MetaCyc Reaction: 2.5.1.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.10

Enzymes and Genes:

Arabidopsis thaliana col :
Capsicum annuum : farnesyl diphosphate synthase Inferred from experiment : GGPPS
Escherichia coli K-12 substr. MG1655 : farnesyl diphosphate synthase Inferred from experiment : ispA
Ginkgo biloba : ω,E,E-farnesyl diphosphate synthase Inferred from experiment : FPS
Hevea brasiliensis : farnesyl diphosphate synthase Inferred from experiment : hbgg
Homo sapiens :
Methanothermobacter marburgensis Marburg : short chain isoprenyl diphosphate synthase Inferred from experiment : idsA
Mycobacterium tuberculosis H37Rv : ω,E,E-farnesyl diphosphate synthase Inferred from experiment : Rv3398c
Saccharomyces cerevisiae : farnesyl diphosphate synthase Inferred from experiment : FPP1
Solanum lycopersicum : farnesyl diphosphate synthase Inferred from experiment : LeFPS1

In Pathway: all-trans-farnesol biosynthesis , bisabolene biosynthesis , trans, trans-farnesyl diphosphate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (2E,6E)-farnesyl diphosphate synthase

Enzyme Commission Synonyms: farnesyl-diphosphate synthase, geranyl transferase I, prenyltransferase, farnesyl pyrophosphate synθse, farnesylpyrophosphate synθse, geranyltranstransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.0 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.

Citations: [Ogura68, Reed75, Takahashi81, Takahashi82]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02003 , Rhea:19361

Relationship Links: BRENDA:EC:2.5.1.10 , ENZYME:EC:2.5.1.10 , IUBMB-ExplorEnz:EC:2.5.1.10 , UniProt:RELATED-TO:O04882 , UniProt:RELATED-TO:O14230 , UniProt:RELATED-TO:O24241 , UniProt:RELATED-TO:O24242 , UniProt:RELATED-TO:O65004 , UniProt:RELATED-TO:P05369 , UniProt:RELATED-TO:P08524 , UniProt:RELATED-TO:P14324 , UniProt:RELATED-TO:P22939 , UniProt:RELATED-TO:P45204 , UniProt:RELATED-TO:P49349 , UniProt:RELATED-TO:P49350 , UniProt:RELATED-TO:P49351 , UniProt:RELATED-TO:P49352 , UniProt:RELATED-TO:P49353 , UniProt:RELATED-TO:Q8L7F4 , UniProt:RELATED-TO:Q92218 , UniProt:RELATED-TO:Q92235 , UniProt:RELATED-TO:Q92250 , UniProt:RELATED-TO:Q92334 , UniProt:RELATED-TO:Q9CH81 , UniProt:RELATED-TO:Q9JSM0 , UniProt:RELATED-TO:Q9PM32 , UniProt:RELATED-TO:Q08291 , UniProt:RELATED-TO:Q09152 , UniProt:RELATED-TO:Q43315

Credits:
Revised 22-Oct-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ogura68: Ogura K, Nishino T, Seto S (1968). "The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties." J Biochem 64(2);197-203. PMID: 4303505

Reed75: Reed BC, Rilling HC (1975). "Crystallization and partial characterization of prenyltransferase from avian liver." Biochemistry 14(1);50-4. PMID: 1109590

Takahashi81: Takahashi I, Ogura K (1981). "Farnesyl pyrophosphate synthetase from Bacillus subtilis." J Biochem 89(5);1581-7. PMID: 6792191

Takahashi82: Takahashi I, Ogura K (1982). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase." J Biochem 92(5);1527-37. PMID: 6818223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed May 27, 2015, BIOCYC14A.