Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.14.17.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.17.4

Enzymes and Genes:
1-aminocyclopropane-1-carboxylate oxidase Inferred from experiment : PAE12 ( Malus domestica )
1-aminocyclopropane-1-carboxylate oxidase Inferred from experiment : ACO ( Cucumis melo )
aminocyclopropane-1-carboxylate oxidase Inferred from experiment : ACO4 ( Solanum lycopersicum )

In Pathway: ethylene biosynthesis I (plants)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aminocyclopropanecarboxylate oxidase

Enzyme Commission Synonyms: ACC oxidase, ethylene-forming enzyme

Standard Gibbs Free Energy (ΔrG in kcal/mol): -69.29988 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.

Citations: [Thrower01, Charng01, Zhang97a, Zhang95a]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R07214 , Rhea:23640

Relationship Links: BRENDA:EC:1.14.17.4 , ENZYME:EC:1.14.17.4 , IUBMB-ExplorEnz:EC:1.14.17.4


References

Charng01: Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF (2001). "The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase." Arch Biochem Biophys 385(1);179-85. PMID: 11361015

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Thrower01: Thrower JS, Blalock R, Klinman JP (2001). "Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase." Biochemistry 40(32);9717-24. PMID: 11583172

Zhang95a: Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P (1995). "Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli." Biochem J 307 ( Pt 1);77-85. PMID: 7717997

Zhang97a: Zhang Z, Barlow JN, Baldwin JE, Schofield CJ (1997). "Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase." Biochemistry 36(50);15999-6007. PMID: 9398335


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc11.