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MetaCyc Reaction: 1.14.17.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.17.4

Enzymes and Genes:

Cucumis melo : 1-aminocyclopropane-1-carboxylate oxidase Inferred from experiment : ACO
Malus domestica : 1-aminocyclopropane-1-carboxylate oxidase Inferred from experiment : PAE12
Solanum lycopersicum : aminocyclopropane-1-carboxylate oxidase Inferred from experiment : ACO4

In Pathway: ethylene biosynthesis I (plants)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aminocyclopropanecarboxylate oxidase

Enzyme Commission Synonyms: ACC oxidase, ethylene-forming enzyme

Standard Gibbs Free Energy (ΔrG in kcal/mol): -69.29988 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.

Citations: [Thrower01, Charng01, Zhang97, Zhang95]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R07214 , Rhea:23640

Relationship Links: BRENDA:EC:1.14.17.4 , ENZYME:EC:1.14.17.4 , IUBMB-ExplorEnz:EC:1.14.17.4


References

Charng01: Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF (2001). "The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase." Arch Biochem Biophys 385(1);179-85. PMID: 11361015

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Thrower01: Thrower JS, Blalock R, Klinman JP (2001). "Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase." Biochemistry 40(32);9717-24. PMID: 11583172

Zhang95: Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P (1995). "Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli." Biochem J 307 ( Pt 1);77-85. PMID: 7717997

Zhang97: Zhang Z, Barlow JN, Baldwin JE, Schofield CJ (1997). "Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase." Biochemistry 36(50);15999-6007. PMID: 9398335


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Jul 6, 2015, BIOCYC14A.