MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Cucumis melo: 1-aminocyclopropane-1-carboxylate oxidaseInferred from experiment: ACO
Malus domestica: 1-aminocyclopropane-1-carboxylate oxidaseInferred from experiment: PAE12
Solanum lycopersicum: aminocyclopropane-1-carboxylate oxidaseInferred from experiment: ACO4

In Pathway: ethylene biosynthesis I (plants)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aminocyclopropanecarboxylate oxidase

Enzyme Commission Synonyms: ACC oxidase, ethylene-forming enzyme

Standard Gibbs Free Energy (ΔrG in kcal/mol): -69.29988Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.

Citations: [Thrower01, Charng01, Zhang97, Zhang95a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R07214, Rhea:23640

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Charng01: Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF (2001). "The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase." Arch Biochem Biophys 385(1);179-85. PMID: 11361015

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Thrower01: Thrower JS, Blalock R, Klinman JP (2001). "Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase." Biochemistry 40(32);9717-24. PMID: 11583172

Zhang95a: Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P (1995). "Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli." Biochem J 307 ( Pt 1);77-85. PMID: 7717997

Zhang97: Zhang Z, Barlow JN, Baldwin JE, Schofield CJ (1997). "Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase." Biochemistry 36(50);15999-6007. PMID: 9398335

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC13A.