Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015 (Sat)
twitter

MetaCyc Reaction: 2.8.2.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.8.2.2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alcohol sulfotransferase

Enzyme Commission Synonyms: hydroxysteroid sulfotransferase, 3β-hydroxy steroid sulfotransferase, δ5-3β-hydroxysteroid sulfokinase, 3-hydroxysteroid sulfotransferase, HST, 5α-androstenol sulfotransferase, cholesterol sulfotransferase, dehydroepiandrosterone sulfotransferase, estrogen sulfokinase, estrogen sulfotransferase, steroid alcohol sulfotransferase, steroid sulfokinase, steroid sulfotransferase, sterol sulfokinase, sterol sulfotransferase, alcohol/hydroxysteroid sulfotransferase, 3β-hydroxysteroid sulfotransferase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 18.417023 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase).

Citations: [Lyon81, Lyon80]

Unification Links: KEGG:R00629

Relationship Links: BRENDA:EC:2.8.2.2 , ENZYME:EC:2.8.2.2 , IUBMB-ExplorEnz:EC:2.8.2.2 , UniProt:RELATED-TO:O62648 , UniProt:RELATED-TO:P15709 , UniProt:RELATED-TO:P22789 , UniProt:RELATED-TO:P50234 , UniProt:RELATED-TO:P50235 , UniProt:RELATED-TO:P50236 , UniProt:RELATED-TO:P52841 , UniProt:RELATED-TO:Q06520


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lyon80: Lyon ES, Jakoby WB (1980). "The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases." Arch Biochem Biophys 202(2);474-81. PMID: 6935986

Lyon81: Lyon ES, Marcus CJ, Wang JL, Jakoby WB (1981). "Hydroxysteroid sulfotransferase." Methods Enzymol 77;206-13. PMID: 6173569


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Sep 3, 2015, biocyc12.