MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alcohol sulfotransferase

Enzyme Commission Synonyms: hydroxysteroid sulfotransferase, 3β-hydroxy steroid sulfotransferase, δ5-3β-hydroxysteroid sulfokinase, 3-hydroxysteroid sulfotransferase, HST, 5α-androstenol sulfotransferase, cholesterol sulfotransferase, dehydroepiandrosterone sulfotransferase, estrogen sulfokinase, estrogen sulfotransferase, steroid alcohol sulfotransferase, steroid sulfokinase, steroid sulfotransferase, sterol sulfokinase, sterol sulfotransferase, alcohol/hydroxysteroid sulfotransferase, 3β-hydroxysteroid sulfotransferase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 18.417023 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC steroid sulfotransferase).

Citations: [Lyon81, Lyon80]

Unification Links: KEGG:R00629

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O62648 , UniProt:RELATED-TO:P15709 , UniProt:RELATED-TO:P22789 , UniProt:RELATED-TO:P50234 , UniProt:RELATED-TO:P50235 , UniProt:RELATED-TO:P50236 , UniProt:RELATED-TO:P52841 , UniProt:RELATED-TO:Q06520


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lyon80: Lyon ES, Jakoby WB (1980). "The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases." Arch Biochem Biophys 202(2);474-81. PMID: 6935986

Lyon81: Lyon ES, Marcus CJ, Wang JL, Jakoby WB (1981). "Hydroxysteroid sulfotransferase." Methods Enzymol 77;206-13. PMID: 6173569

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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