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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: NADPH-dependent aldehyde reductaseInferred from experiment: yqhD
NADP+-dependent aldehyde reductaseInferred from experiment: ybbO
aldehyde reductase, NADPH-dependentInferred from experiment: ahr
aldehyde reductase, NADPH-dependentInferred from experiment: yahK

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Instance reactions:
(6E)-8-oxogeraniol + NADP+ ↔ (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

(2E,6E)-farnesol + NADP+ ↔ (2E,6E)-farnesal + NADPH + H+ (

(R)-propane-1,2-diol + NADP+ ← (R)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ ← (S)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ = (S)-lactaldehyde + NADPH + H+ (

n-butanol + NADP+ ↔ butanal + NADPH + H+ (1.1.1.-)

ethanol + NADP+ = acetaldehyde + NADPH + H+ (

(E)-2-pentenol + NADP+ ← (E)-2-pentenal + NADPH + H+ (1.1.1.-)

xylitol + NADP+ ↔ D-xylopyranose + NADPH + H+ (1.1.1.-)

L-arabitol + NADP+ ↔ L-arabinopyranose + NADPH + H+ (

glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ (

glycerol + NADP+ ← L-glyceraldehyde + NADPH + H+ (

(E)-2-hexenol + NADP+ ← (E)-2-hexenal + NADPH + H+ (1.1.1.-)

galactitol + NADP+ ↔ D-galactopyranose + NADPH + H+ (

geraniol + NADP+ → geranial + NADPH + H+ (

(6E)-8-hydroxygeranial + NADP+ → (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

Enzyme Commission Primary Name: alcohol dehydrogenase (NADP+)

Enzyme Commission Synonyms: aldehyde reductase (NADPH2), NADP-alcohol dehydrogenase, NADP+-aldehyde reductase, NADP+-dependent aldehyde reductase, NADPH-aldehyde reductase, NADPH-dependent aldehyde reductase, nonspecific succinic semialdehyde reductase, ALR 1, low-Km aldehyde reductase, high-Km aldehyde reductase, alcohol dehydrogenase (NADP)

Taxonomic Range: Bacteria , Fungi, Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 23.45575Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC, glucuronate reductase, EC, mevaldate reductase (NADPH) and EC, lactaldehyde reductase (NADPH). Re-specific with respect to NADPH.

Citations: [Bosron72, Tabakoff70, Murata85, Chen03b]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R07328, Rhea:15940

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O06007, UniProt:RELATED-TO:P0A4X0, UniProt:RELATED-TO:P0A4X1, UniProt:RELATED-TO:P14550, UniProt:RELATED-TO:P14941, UniProt:RELATED-TO:P25377, UniProt:RELATED-TO:P35630, UniProt:RELATED-TO:P75214, UniProt:RELATED-TO:P75691, UniProt:RELATED-TO:P77990, UniProt:RELATED-TO:Q7M0Z4, UniProt:RELATED-TO:Q7M543, UniProt:RELATED-TO:Q7M544, UniProt:RELATED-TO:Q9PMC1, UniProt:RELATED-TO:Q04894

Revised 06-Sep-2012 by Caspi R, SRI International


Bosron72: Bosron WF, Prairie RL (1972). "Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex." J Biol Chem 247(14);4480-5. PMID: 4402936

Chen03b: Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH (2003). "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae." Yeast 20(6);545-54. PMID: 12722185

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murata85: Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A (1985). "Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae." Eur J Biochem 151(3);631-6. PMID: 3896793

Tabakoff70: Tabakoff B, Erwin VG (1970). "Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain." J Biol Chem 245(12);3263-8. PMID: 4393513

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Dec 31, 2001, biocyc12.