twitter

MetaCyc Reaction: 1.1.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.1

Enzymes and Genes:

Chlamydomonas reinhardtii : alcohol dehydrogenase / acetaldehyde dehydrogenase Inferred from experiment : ADH1
Clostridium acetobutylicum ATCC 824 : alcohol/aldehyde dehydrogenase Inferred from experiment : adhE
Corynebacterium glutamicum ATCC 13032 :
Escherichia coli K-12 substr. MG1655 :
Glycine max : alcohol dehydrogenase Inferred from experiment
Homo sapiens : alcohol dehydrogenase 2 Traceable author statement to experimental support : ADH1B
Mycobacterium tuberculosis H37Rv : alcohol dehydrogenase : adhE
Nicotiana tabacum : alcohol dehydrogenase Inferred from experiment : ADH2
Pelobacter acetylenicus : alcohol dehydrogenase Inferred from experiment
Pisum sativum : alcohol dehydrogenase Inferred from experiment : adh
Ralstonia eutropha JMP134 : furfuryl alcohol dehydrogenase Inferred from experiment : furX
Saccharomyces cerevisiae :
Solanum tuberosum : alcohol dehydrogenase Inferred from experiment : ADH1
Streptococcus mutans : NAD-dependent alcohol dehydrogenase Inferred from experiment : adhE
Zea mays : alcohol dehydrogenase Inferred from experiment : ADH1

In Pathway: ethanol degradation I , ethanol degradation II , pyruvate fermentation to ethanol I , pyruvate fermentation to ethanol II , heterolactic fermentation , acetylene degradation , mixed acid fermentation , acetaldehyde biosynthesis I , pyruvate fermentation to ethanol III , superpathway of fermentation (Chlamydomonas reinhardtii) , chitin degradation to ethanol

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+ (1.1.1.1)

Enzyme Commission Primary Name: alcohol dehydrogenase

Enzyme Commission Synonyms: aldehyde reductase, ADH, alcohol dehydrogenase (NAD), aliphatic alcohol dehydrogenase, ethanol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, primary alcohol dehydrogenase, yeast alcohol dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.1017761 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

Citations: [Jornvall77a, THEORELL58]

Unification Links: KEGG:R00754 , Rhea:25290

Relationship Links: BRENDA:EC:1.1.1.1 , ENZYME:EC:1.1.1.1 , IUBMB-ExplorEnz:EC:1.1.1.1


References

Jornvall77a: Jornvall H (1977). "Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects." Eur J Biochem 72(3);443-52. PMID: 320001

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

THEORELL58: THEORELL H (1958). "Kinetics and equilibria in the liver alcohol dehydrogenase system." Adv Enzymol Relat Subj Biochem 20;31-49. PMID: 13605979


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc12.