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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.1

Enzymes and Genes:
alcohol dehydrogenase V Inferred from experiment : ADH5 ( Saccharomyces cerevisiae )
alcohol dehydrogenase / acetaldehyde dehydrogenase Inferred from experiment : ADH1 ( Chlamydomonas reinhardtii )
furfuryl alcohol dehydrogenase Inferred from experiment : furX ( Ralstonia eutropha JMP134 )
alcohol/aldehyde dehydrogenase Inferred from experiment : adhE ( Clostridium acetobutylicum ATCC 824 )
alcohol dehydrogenase Inferred from experiment : adh ( Pisum sativum )
alcohol dehydrogenase Inferred from experiment : ADH1 ( Solanum tuberosum )
alcohol dehydrogenase Inferred from experiment : ADH1 ( Zea mays )
alcohol dehydrogenase Inferred from experiment ( Pelobacter acetylenicus )
NAD-dependent alcohol dehydrogenase Inferred from experiment : adhE ( Streptococcus mutans )
alcohol dehydrogenase Inferred from experiment : ADH2 ( Nicotiana tabacum )
alcohol dehydrogenase Inferred from experiment ( Glycine max )
alcohol dehydrogenase 2 Traceable author statement to experimental support : ADH1B ( Homo sapiens )
alcohol dehydrogenase : adhE ( Mycobacterium tuberculosis H37Rv )
alcohol dehydrogenase I Inferred from experiment : ADH1 ( Saccharomyces cerevisiae )
alcohol dehydrogenase II Inferred from experiment : ADH2 ( Saccharomyces cerevisiae )
alcohol dehydrogenase III Inferred from experiment : ADH3 ( Saccharomyces cerevisiae )
ethanol dehydrogenase / alcohol dehydrogenase Inferred from experiment : adhP ( Escherichia coli K-12 substr. MG1655 )
aldehyde-alcohol dehydrogenase Inferred from experiment : adhE ( Escherichia coli K-12 substr. MG1655 )

In Pathway: ethanol degradation I , ethanol degradation II , pyruvate fermentation to ethanol I , pyruvate fermentation to ethanol II , heterolactic fermentation , acetylene degradation , mixed acid fermentation , acetoin degradation , acetaldehyde biosynthesis I , pyruvate fermentation to ethanol III , superpathway of fermentation (Chlamydomonas reinhardtii) , chitin degradation to ethanol

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+ (1.1.1.1)

Enzyme Commission Primary Name: alcohol dehydrogenase

Enzyme Commission Synonyms: aldehyde reductase, ADH, alcohol dehydrogenase (NAD), aliphatic alcohol dehydrogenase, ethanol dehydrogenase, NAD-dependent alcohol dehydrogenase, NAD-specific aromatic alcohol dehydrogenase, NADH-alcohol dehydrogenase, NADH-aldehyde dehydrogenase, primary alcohol dehydrogenase, yeast alcohol dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.1017761 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

Citations: [Jornvall77, THEORELL58]

Gene-Reaction Schematic: ?

Instance reactions of [a primary alcohol + NAD+ ↔ an aldehyde + NADH + H+] (1.1.1.1):
i1: n-butanol + NAD+ ← butanal + NADH + H+ (1.1.1.-)

i2: ethanol + NAD+ ↔ acetaldehyde + NADH + H+ (1.1.1.1)
i3: phytol + NAD+ → phytenal + NADH + H+ (1.1.1.1)

i4: n-propanol + NAD+ ↔ propanal + NADH + H+ (1.1.1.1)

Unification Links: KEGG:R00754 , Rhea:25290

Relationship Links: BRENDA:EC:1.1.1.1 , ENZYME:EC:1.1.1.1 , IUBMB-ExplorEnz:EC:1.1.1.1


References

Jornvall77: Jornvall H (1977). "Differences between alcohol dehydrogenases. Structural properties and evolutionary aspects." Eur J Biochem 72(3);443-52. PMID: 320001

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

THEORELL58: THEORELL H (1958). "Kinetics and equilibria in the liver alcohol dehydrogenase system." Adv Enzymol Relat Subj Biochem 20;31-49. PMID: 13605979


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc13.