Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.3.3.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.3.6

Enzymes and Genes:
acyl coA dehydrogenase Inferred from experiment : Mlut_11700 ( Micrococcus luteus )
fatty-acyl coenzyme A oxidase : POX1 ( Saccharomyces cerevisiae )
peroxisomal acyl-coenzyme A oxidase 1 : ACOX1 ( Homo sapiens )
acyl-CoA oxidase Inferred from experiment : AT3G51840 ( Arabidopsis thaliana col )
acyl-CoA oxidase Inferred from experiment Inferred by computational analysis : AT1G06290 ( Arabidopsis thaliana col )
acyl-CoA oxidase Inferred from experiment : AT5G65110 ( Arabidopsis thaliana col )
acyl-CoA oxidase Inferred from experiment : AT4G16760 ( Arabidopsis thaliana col )

In Pathway: methyl ketone biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Instance reaction:
octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (1.3.3.6)

Enzyme Commission Primary Name: acyl-CoA oxidase

Enzyme Commission Synonyms: fatty acyl-CoA oxidase, acyl coenzyme A oxidase, fatty acyl-coenzyme A oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 10.292236 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.

Citations: [Kawaguchi80, Osumi80]

Gene-Reaction Schematic: ?

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + oxygen → a trans-2-enoyl-CoA + hydrogen peroxide] (1.3.3.6):
i1: octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (1.3.3.6)

Unification Links: KEGG:R00388 , PIR:A54942 , PIR:B54942 , PIR:I38095 , PIR:JC4563 , PIR:OXCKAX , PIR:OXCKP2 , PIR:OXCKPM , PIR:OXCKX , PIR:OXCKX4 , PIR:OXCKX5 , PIR:OXRTA1 , PIR:OXRTA2 , PIR:S40722 , PIR:S64224 , PIR:T04418 , PIR:T52120 , PIR:T52121 , UniProt:O23977 , UniProt:O65201 , UniProt:O65202 , UniProt:P06598 , UniProt:P07872 , UniProt:P11356 , UniProt:P13711 , UniProt:P34355 , UniProt:Q00468 , UniProt:Q15067

Relationship Links: BRENDA:EC:1.3.3.6 , ENZYME:EC:1.3.3.6 , IUBMB-ExplorEnz:EC:1.3.3.6 , UniProt:RELATED-TO:O23977 , UniProt:RELATED-TO:O65201 , UniProt:RELATED-TO:O65202 , UniProt:RELATED-TO:P06598 , UniProt:RELATED-TO:P07872 , UniProt:RELATED-TO:P11356 , UniProt:RELATED-TO:P13711 , UniProt:RELATED-TO:P34355 , UniProt:RELATED-TO:Q00468 , UniProt:RELATED-TO:Q15067


References

Kawaguchi80: Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto T, Kikuchi T, Ando M, Okuda S (1980). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase." J Biochem 88(5);1481-6. PMID: 7462191

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Osumi80: Osumi T, Hashimoto T, Ui N (1980). "Purification and properties of acyl-CoA oxidase from rat liver." J Biochem 87(6);1735-46. PMID: 7400120


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14A.