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MetaCyc Reaction: 1.3.3.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.3.6

Enzymes and Genes:

Arabidopsis thaliana col : acyl-CoA oxidase Inferred from experiment : AT4G16760
acyl-CoA oxidase Inferred from experiment : AT5G65110
acyl-CoA oxidase Inferred from experiment Inferred by computational analysis : AT1G06290
acyl-CoA oxidase Inferred from experiment : AT3G51840
Homo sapiens : peroxisomal acyl-coenzyme A oxidase 1 : ACOX1
Micrococcus luteus : acyl coA dehydrogenase Inferred from experiment : Mlut_11700
Saccharomyces cerevisiae : fatty-acyl coenzyme A oxidase : POX1

In Pathway: methyl ketone biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Instance reactions:
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + hydrogen peroxide (1.3.3.6)

octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (1.3.3.6)

Enzyme Commission Primary Name: acyl-CoA oxidase

Enzyme Commission Synonyms: fatty acyl-CoA oxidase, acyl coenzyme A oxidase, fatty acyl-coenzyme A oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 10.292236 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.

Citations: [Kawaguchi80, Osumi80]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [an acyl-CoA + oxygen → a trans-2-enoyl-CoA + hydrogen peroxide] (1.3.3.6):
i1: (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + hydrogen peroxide (1.3.3.6)

i2: octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (1.3.3.6)

Unification Links: KEGG:R00388 , PIR:A54942 , PIR:B54942 , PIR:I38095 , PIR:JC4563 , PIR:OXCKAX , PIR:OXCKP2 , PIR:OXCKPM , PIR:OXCKX , PIR:OXCKX4 , PIR:OXCKX5 , PIR:OXRTA1 , PIR:OXRTA2 , PIR:S40722 , PIR:S64224 , PIR:T04418 , PIR:T52120 , PIR:T52121 , UniProt:O23977 , UniProt:O65201 , UniProt:O65202 , UniProt:P06598 , UniProt:P07872 , UniProt:P11356 , UniProt:P13711 , UniProt:P34355 , UniProt:Q00468 , UniProt:Q15067

Relationship Links: BRENDA:EC:1.3.3.6 , ENZYME:EC:1.3.3.6 , IUBMB-ExplorEnz:EC:1.3.3.6 , UniProt:RELATED-TO:O23977 , UniProt:RELATED-TO:O65201 , UniProt:RELATED-TO:O65202 , UniProt:RELATED-TO:P06598 , UniProt:RELATED-TO:P07872 , UniProt:RELATED-TO:P11356 , UniProt:RELATED-TO:P13711 , UniProt:RELATED-TO:P34355 , UniProt:RELATED-TO:Q00468 , UniProt:RELATED-TO:Q15067


References

Kawaguchi80: Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto T, Kikuchi T, Ando M, Okuda S (1980). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase." J Biochem 88(5);1481-6. PMID: 7462191

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Osumi80: Osumi T, Hashimoto T, Ui N (1980). "Purification and properties of acyl-CoA oxidase from rat liver." J Biochem 87(6);1735-46. PMID: 7400120


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 29, 2015, biocyc13.