MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: acyl-CoA oxidaseInferred from experiment: AT4G16760
acyl-CoA oxidaseInferred from experiment: AT5G65110
acyl-CoA oxidaseInferred from experimentInferred by computational analysis: AT1G06290
acyl-CoA oxidaseInferred from experiment: AT3G51840
Homo sapiens: peroxisomal acyl-coenzyme A oxidase 1: ACOX1
Micrococcus luteus: acyl coA dehydrogenaseInferred from experiment: Mlut_11700
Saccharomyces cerevisiae: fatty-acyl coenzyme A oxidase: POX1

In Pathway: methyl ketone biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Instance reactions:
octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (

(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + hydrogen peroxide (

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + hydrogen peroxide (

Enzyme Commission Primary Name: acyl-CoA oxidase

Enzyme Commission Synonyms: fatty acyl-CoA oxidase, acyl coenzyme A oxidase, fatty acyl-coenzyme A oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 10.292236Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.

Citations: [Kawaguchi80, Osumi80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [an acyl-CoA + oxygen → a trans-2-enoyl-CoA + hydrogen peroxide] (
i2: (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + hydrogen peroxide (

i3: (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + oxygen → (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + hydrogen peroxide (

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + oxygen → a trans-2-enoyl-CoA + hydrogen peroxide] (
i1: octanoyl-CoA + oxygen → trans-oct-2-enoyl-CoA + hydrogen peroxide (

Unification Links: KEGG:R00388, PIR:A54942, PIR:B54942, PIR:I38095, PIR:JC4563, PIR:OXCKAX, PIR:OXCKP2, PIR:OXCKPM, PIR:OXCKX, PIR:OXCKX4, PIR:OXCKX5, PIR:OXRTA1, PIR:OXRTA2, PIR:S40722, PIR:S64224, PIR:T04418, PIR:T52120, PIR:T52121, UniProt:O23977, UniProt:O65201, UniProt:O65202, UniProt:P06598, UniProt:P07872, UniProt:P11356, UniProt:P13711, UniProt:P34355, UniProt:Q00468, UniProt:Q15067

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O23977, UniProt:RELATED-TO:O65201, UniProt:RELATED-TO:O65202, UniProt:RELATED-TO:P06598, UniProt:RELATED-TO:P07872, UniProt:RELATED-TO:P11356, UniProt:RELATED-TO:P13711, UniProt:RELATED-TO:P34355, UniProt:RELATED-TO:Q00468, UniProt:RELATED-TO:Q15067


Kawaguchi80: Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto T, Kikuchi T, Ando M, Okuda S (1980). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase." J Biochem 88(5);1481-6. PMID: 7462191

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Osumi80: Osumi T, Hashimoto T, Ui N (1980). "Purification and properties of acyl-CoA oxidase from rat liver." J Biochem 87(6);1735-46. PMID: 7400120

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13B.