MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Torpedo californica: acetylcholinesteraseInferred from experiment: ache

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetylcholinesterase

Enzyme Commission Synonyms: true cholinesterase, choline esterase I, cholinesterase, acetylthiocholinesterase, acetylcholine hydrolase, acetyl.β-methylcholinesterase, AcCholE

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.2871246Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a variety of acetic esters; also catalyses transacetylations.

Citations: [NACHMANSOHN51, Leuzinger68, Ciliv72, BERGMANN58, ZITTLE55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01026, Rhea:17561

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O61371, UniProt:RELATED-TO:O61372, UniProt:RELATED-TO:O61459, UniProt:RELATED-TO:P04058, UniProt:RELATED-TO:P07140, UniProt:RELATED-TO:P07692, UniProt:RELATED-TO:P21836, UniProt:RELATED-TO:P22303, UniProt:RELATED-TO:P36196, UniProt:RELATED-TO:P37136, UniProt:RELATED-TO:P38433, UniProt:RELATED-TO:Q7LZ27, UniProt:RELATED-TO:Q7LZG1, UniProt:RELATED-TO:Q7LZJ6, UniProt:RELATED-TO:Q7M2N6, UniProt:RELATED-TO:Q7M382, UniProt:RELATED-TO:Q8MXC4, UniProt:RELATED-TO:Q8MXC5, UniProt:RELATED-TO:Q8MXC6, UniProt:RELATED-TO:Q8MXC7, UniProt:RELATED-TO:Q8MXC8, UniProt:RELATED-TO:Q8MXC9, UniProt:RELATED-TO:Q95P20, UniProt:RELATED-TO:Q95WV7, UniProt:RELATED-TO:Q9PWR0, UniProt:RELATED-TO:Q9TR27, UniProt:RELATED-TO:Q9TX11, UniProt:RELATED-TO:Q03637


BERGMANN58: BERGMANN F, RIMON S, SEGAL R (1958). "Effect of pH on the activity of eel esterase towards different substrates." Biochem J 68(3);493-9. PMID: 13522650

Ciliv72: Ciliv G, Ozand PT (1972). "Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior." Biochim Biophys Acta 284(1);136-56. PMID: 5073758

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Leuzinger68: Leuzinger W, Baker AL, Cauvin E (1968). "Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point." Proc Natl Acad Sci U S A 59(2);620-3. PMID: 5238989

NACHMANSOHN51: NACHMANSOHN D, WILSON IB (1951). "The enzymic hydrolysis and synthesis of acetylcholine." Adv Enzymol Relat Subj Biochem 12;259-339. PMID: 14885021

ZITTLE55: ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R (1955). "Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction." Arch Biochem Biophys 56(2);469-75. PMID: 14377597

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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