|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Penicillium chrysogenum:||δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase: PCBAB|
In Pathway: isopenicillin N biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzyme Commission Synonyms: L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, ACV synthetase, L-α-aminoadipyl-cysteinyl-valine synthetase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -59.290527 [Latendresse13]
Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that a water molecules has been added to the reactants. The water molecule was added based on the original article describing the enzyme catalyzing the reaction. The NC-IUBMB reaction does not contain a water molecule.
The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.
Theilgaard97: Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (1997). "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum." Biochem J 327 ( Pt 1);185-91. PMID: 9355751
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