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MetaCyc Reaction: 6.3.2.26

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 6.3.2.26

Enzymes and Genes:

Penicillium chrysogenum: δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetaseInferred from experiment: PCBAB

In Pathway: isopenicillin N biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Enzyme Commission Synonyms: L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, ACV synthetase, L-α-aminoadipyl-cysteinyl-valine synthetase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -59.290527Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that a water molecules has been added to the reactants. The water molecule was added based on the original article describing the enzyme catalyzing the reaction. The NC-IUBMB reaction does not contain a water molecule.

The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.

Citations: [Theilgaard97, Byford97]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04870, Rhea:23196

Relationship Links: BRENDA:EC:6.3.2.26, ENZYME:EC:6.3.2.26, IUBMB-ExplorEnz:EC:6.3.2.26


References

Byford97: Byford MF, Baldwin JE, Shiau CY, Schofield CJ (1997). "The Mechanism of ACV Synthetase." Chem Rev 97(7);2631-2650. PMID: 11851475

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Theilgaard97: Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (1997). "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum." Biochem J 327 ( Pt 1);185-91. PMID: 9355751


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc13.