|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase : PCBAB ( Penicillium chrysogenum )
In Pathway: isopenicillin N biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzyme Commission Synonyms: L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synθse, ACV synθse, L-α-aminoadipyl-cysteinyl-valine synθse
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -59.290527 [Latendresse13]
Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that a water molecules has been added to the reactants. The water molecule was added based on the original article describing the enzyme catalyzing the reaction. The NC-IUBMB reaction does not contain a water molecule.
The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.
Theilgaard97: Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (1997). "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum." Biochem J 327 ( Pt 1);185-91. PMID: 9355751
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