Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 6.3.2.26

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.2.26

Enzymes and Genes:
δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase Inferred from experiment : PCBAB ( Penicillium chrysogenum )

In Pathway: isopenicillin N biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Enzyme Commission Synonyms: L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synθse, ACV synθse, L-α-aminoadipyl-cysteinyl-valine synθse

Standard Gibbs Free Energy (ΔrG in kcal/mol): -59.290527 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is different from the one described by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). The reaction is different in that a water molecules has been added to the reactants. The water molecule was added based on the original article describing the enzyme catalyzing the reaction. The NC-IUBMB reaction does not contain a water molecule.

The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.

Citations: [Theilgaard97, Byford97]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04870 , Rhea:23196

Relationship Links: BRENDA:EC:6.3.2.26 , ENZYME:EC:6.3.2.26 , IUBMB-ExplorEnz:EC:6.3.2.26


References

Byford97: Byford MF, Baldwin JE, Shiau CY, Schofield CJ (1997). "The Mechanism of ACV Synthetase." Chem Rev 97(7);2631-2650. PMID: 11851475

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Theilgaard97: Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (1997). "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum." Biochem J 327 ( Pt 1);185-91. PMID: 9355751


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc13.