MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 4-coumarate coenzyme A ligase 3Inferred from experiment: 4CL3
4-coumarate coenzyme A ligase 1Inferred from experiment: 4CL1
Sphingomonas sp. SYK6: feruloyl-CoA synthetaseInferred from experiment: ferA

In Pathway: ferulate degradation, suberin monomers biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trans-feruloyl-CoA synthase

Enzyme Commission Synonyms: trans-feruloyl-CoA synthetase, trans-ferulate:CoASH ligase (ATP-hydrolysing), ferulate:CoASH ligase (ATP-hydrolysing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.711792Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+. It has not yet been established whether AMP + diphosphate or ADP + phosphate are formed in this reaction [Narbad98].

Citations: [Pometto83]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02194

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Narbad98: Narbad A, Gasson MJ (1998). "Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens." Microbiology 144 ( Pt 5);1397-405. PMID: 9611814

Pometto83: Pometto AL, Crawford DL (1983). "Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus." Appl Environ Microbiol 45(5);1582-5. PMID: 6870241

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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