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MetaCyc Reaction: 4.2.3.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.3.10

Enzymes and Genes:

Foeniculum vulgare : (-)-endo-fenchol cyclase Inferred from experiment
(-)-endo-fenchol cyclase Inferred from experiment
Ocimum basilicum : monoterpene synthase Inferred from experiment : FES

In Pathway: fenchol biosynthesis I , fenchone biosynthesis , fenchol biosynthesis II

Supersedes EC number: 4.6.1.8

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (-)-endo-fenchol synthase

Enzyme Commission Synonyms: (-)-endo-fenchol cyclase, geranyl pyrophosphate:(-)-endo-fenchol cyclase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -58.642975 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
(3R)-linalyl diphosphate is an intermediate in the reaction.

Citations: [Croteau88, Croteau89]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02004 , Rhea:20565

Relationship Links: BRENDA:EC:4.2.3.10 , ENZYME:EC:4.2.3.10 , IUBMB-ExplorEnz:EC:4.2.3.10


References

Croteau88: Croteau R, Satterwhite DM, Wheeler CJ, Felton NM (1988). "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol." J Biol Chem 263(30);15449-53. PMID: 3170591

Croteau89: Croteau R, Miyazaki JH, Wheeler CJ (1989). "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare)." Arch Biochem Biophys 269(2);507-16. PMID: 2919880

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, biocyc12.