Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.6.3.44

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Transport Energised by P-P Bond Hydrolysis
Reactions Classified By Conversion Type Simple Reactions Transport Reactions Transport Energised by P-P Bond Hydrolysis
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.3.44

Reaction Locations: extracellular space/cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: xenobiotic-transporting ATPase

Enzyme Commission Synonyms: multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, ATP phosphohydrolase (steroid-exporting)

Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione-drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC 3.6.3.1) activity.

Citations: [Mahe96, Nagao95, Prasad95, vanVeen98, Loe98, Keppler97, Frijters96, Bellamy96]

Relationship Links: BRENDA:EC:3.6.3.44 , ENZYME:EC:3.6.3.44 , IUBMB-ExplorEnz:EC:3.6.3.44


References

Bellamy96: Bellamy WT (1996). "P-glycoproteins and multidrug resistance." Annu Rev Pharmacol Toxicol 36;161-83. PMID: 8725386

Frijters96: Frijters CM, Ottenhoff R, Van Wijland MJ, Van Nieuwkerk C, Groen AK, Oude Elferink RP (1996). "Influence of bile salts on hepatic mdr2 P-glycoprotein expression." Adv Enzyme Regul 36;351-63. PMID: 8869755

Keppler97: Keppler D, Konig J, Buchler M (1997). "The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes." Adv Enzyme Regul 37;321-33. PMID: 9381978

Loe98: Loe DW, Deeley RG, Cole SP (1998). "Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione." Cancer Res 58(22);5130-6. PMID: 9823323

Mahe96: Mahe Y, Lemoine Y, Kuchler K (1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo." J Biol Chem 271(41);25167-72. PMID: 8810273

Nagao95: Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M (1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily." J Bacteriol 177(6);1536-43. PMID: 7883711

Prasad95: Prasad R, De Wergifosse P, Goffeau A, Balzi E (1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals." Curr Genet 27(4);320-9. PMID: 7614555

vanVeen98: van Veen HW, Konings WN (1998). "The ABC family of multidrug transporters in microorganisms." Biochim Biophys Acta 1365(1-2);31-6. PMID: 9693718


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.