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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Transport reaction diagram

Reaction Locations: extracellular space/cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: xenobiotic-transporting ATPase

Enzyme Commission Synonyms: multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, ATP phosphohydrolase (steroid-exporting)

Taxonomic Range: Fungi, Viridiplantae, Metazoa, Bacteria

Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione-drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC activity.

Citations: [Mahe96, Nagao95, Prasad95, vanVeen98, Loe98, Keppler97, Frijters96, Bellamy96]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bellamy96: Bellamy WT (1996). "P-glycoproteins and multidrug resistance." Annu Rev Pharmacol Toxicol 36;161-83. PMID: 8725386

Frijters96: Frijters CM, Ottenhoff R, Van Wijland MJ, Van Nieuwkerk C, Groen AK, Oude Elferink RP (1996). "Influence of bile salts on hepatic mdr2 P-glycoprotein expression." Adv Enzyme Regul 36;351-63. PMID: 8869755

Keppler97: Keppler D, Konig J, Buchler M (1997). "The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes." Adv Enzyme Regul 37;321-33. PMID: 9381978

Loe98: Loe DW, Deeley RG, Cole SP (1998). "Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione." Cancer Res 58(22);5130-6. PMID: 9823323

Mahe96: Mahe Y, Lemoine Y, Kuchler K (1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo." J Biol Chem 271(41);25167-72. PMID: 8810273

Nagao95: Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M (1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily." J Bacteriol 177(6);1536-43. PMID: 7883711

Prasad95: Prasad R, De Wergifosse P, Goffeau A, Balzi E (1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals." Curr Genet 27(4);320-9. PMID: 7614555

vanVeen98: van Veen HW, Konings WN (1998). "The ABC family of multidrug transporters in microorganisms." Biochim Biophys Acta 1365(1-2);31-6. PMID: 9693718

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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