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MetaCyc Reaction: 3.6.3.21

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Energised by P-P Bond Hydrolysis
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.6.3.21

Transport reaction diagram

Reaction Locations: extracellular space/cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: polar-amino-acid-transporting ATPase

Enzyme Commission Synonyms: histidine permease

Enzyme Commission Summary:
ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.

Citations: [Kuan95, Saier98, Nikaido97, Walshaw97]

Relationship Links: BRENDA:EC:3.6.3.21, ENZYME:EC:3.6.3.21, IUBMB-ExplorEnz:EC:3.6.3.21


References

Kuan95: Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases." Res Microbiol 146(4);271-8. PMID: 7569321

Nikaido97: Nikaido K, Liu PQ, Ames GF (1997). "Purification and characterization of HisP, the ATP-binding subunit of a traffic ATPase (ABC transporter), the histidine permease of Salmonella typhimurium. Solubility, dimerization, and ATPase activity." J Biol Chem 272(44);27745-52. PMID: 9346917

Saier98: Saier MH (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya." Adv Microb Physiol 40;81-136. PMID: 9889977

Walshaw97: Walshaw DL, Lowthorpe S, East A, Poole PS (1997). "Distribution of a sub-class of bacterial ABC polar amino acid transporter and identification of an N-terminal region involved in solute specificity." FEBS Lett 414(2);397-401. PMID: 9315727


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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