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MetaCyc Reaction: 3.5.5.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.5.7

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aliphatic nitrilase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.1898727 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Preferentially hydrolyses aliphatic nitriles, some of which are apparently not substrates for other known nitrilases (EC 3.5.5.1). Substrates include crotononitrile, acrylonitrile and glutaronitrile.

Citations: [Kobayashi92, Pace01]

Relationship Links: BRENDA:EC:3.5.5.7 , ENZYME:EC:3.5.5.7 , IUBMB-ExplorEnz:EC:3.5.5.7 , Rhea:RELATED-TO:21724


References

Kobayashi92: Kobayashi M, Yanaka N, Nagasawa T, Yamada H (1992). "Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue." Biochemistry 1992;31(37);9000-7. PMID: 1390687

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Pace01: Pace HC, Brenner C (2001). "The nitrilase superfamily: classification, structure and function." Genome Biol 2(1);REVIEWS0001. PMID: 11380987


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, biocyc13.