|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Supersedes EC number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: pro-opiomelanocortin converting enzyme
Enzyme Commission Synonyms: prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE
Enzyme Commission Summary:
This enzyme catalyzes cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side.
A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle.
Estivariz89: Estivariz FE, Birch NP, Loh YP (1989). "Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme." J Biol Chem 264(30);17796-801. PMID: 2553692
Loh85: Loh YP, Parish DC, Tuteja R (1985). "Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles." J Biol Chem 260(12);7194-205. PMID: 2987247
Loh86: Loh YP (1986). "Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme." J Biol Chem 261(26);11949-55. PMID: 3017955
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