Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.23.17

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.23.17

Supersedes EC number: 3.4.99.38

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: pro-opiomelanocortin converting enzyme

Enzyme Commission Synonyms: prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE

Enzyme Commission Summary:
This enzyme catalyzes cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side.

A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle.

Citations: [Loh85, Loh86, Estivariz89]

Relationship Links: BRENDA:EC:3.4.23.17 , ENZYME:EC:3.4.23.17 , IUBMB-ExplorEnz:EC:3.4.23.17


References

Estivariz89: Estivariz FE, Birch NP, Loh YP (1989). "Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme." J Biol Chem 264(30);17796-801. PMID: 2553692

Loh85: Loh YP, Parish DC, Tuteja R (1985). "Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles." J Biol Chem 260(12);7194-205. PMID: 2987247

Loh86: Loh YP (1986). "Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme." J Biol Chem 261(26);11949-55. PMID: 3017955


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, biocyc13.