|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions|
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: gingipain K
Enzyme Commission Synonyms: Lys-gingipain, PrtP proteinase
Enzyme Commission Summary:
An endopeptidase with strict specificity for lysyl bonds. Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.
Curtis02: Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B (2002). "Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor." Infect Immun 70(12);6968-75. PMID: 12438376
Pike94: Pike R, McGraw W, Potempa J, Travis J (1994). "Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins." J Biol Chem 269(1);406-11. PMID: 8276827
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