MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: gingipain K

Enzyme Commission Synonyms: Lys-gingipain, PrtP proteinase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -17.814125 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
An endopeptidase with strict specificity for lysyl bonds. Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.

Citations: [Pike94, Curtis02]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Curtis02: Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B (2002). "Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor." Infect Immun 70(12);6968-75. PMID: 12438376

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Pike94: Pike R, McGraw W, Potempa J, Travis J (1994). "Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins." J Biol Chem 269(1);406-11. PMID: 8276827

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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