|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: gingipain K
Enzyme Commission Synonyms: Lys-gingipain, PrtP proteinase
Taxonomic Range: Bacteria
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -17.814125 [Latendresse13]
Enzyme Commission Summary:
An endopeptidase with strict specificity for lysyl bonds. Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.
Curtis02: Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B (2002). "Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor." Infect Immun 70(12);6968-75. PMID: 12438376
Pike94: Pike R, McGraw W, Potempa J, Travis J (1994). "Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins." J Biol Chem 269(1);406-11. PMID: 8276827
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