Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.11.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.11.9

Enzymes and Genes:
proline aminopeptidase P II Inferred from experiment : pepP ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: Xaa-Pro aminopeptidase

Enzyme Commission Synonyms: proline aminopeptidase, aminopeptidase P, aminoacylproline aminopeptidase, X-Pro aminopeptidase

Enzyme Commission Summary:
This enzyme catalyzes release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

A Mn2+-dependent, generally membrane-bound enzyme present in both mammalian and bacterial cells. In peptidase family M24 (methionyl aminopeptidase family).

Citations: [Yoshimoto94, Yoshimoto88, Yaron68, Fleminger82, Orawski87, Hooper90, Yaron70]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.4.11.9 , ENZYME:EC:3.4.11.9 , IUBMB-ExplorEnz:EC:3.4.11.9 , UniProt:RELATED-TO:P0A3Z2 , UniProt:RELATED-TO:P15034 , UniProt:RELATED-TO:P44881 , UniProt:RELATED-TO:P47566 , UniProt:RELATED-TO:Q09795 , UniProt:RELATED-TO:Q95333


References

Fleminger82: Fleminger G, Carmel A, Goldenberg D, Yaron A (1982). "Fluorogenic substrates for bacterial aminopeptidase P and its analogs detected in human serum and calf lung." Eur J Biochem 125(3);609-15. PMID: 6749499

Hooper90: Hooper NM, Hryszko J, Turner AJ (1990). "Purification and characterization of pig kidney aminopeptidase P. A glycosyl-phosphatidylinositol-anchored ectoenzyme." Biochem J 267(2);509-15. PMID: 2139778

Orawski87: Orawski AT, Susz JP, Simmons WH (1987). "Aminopeptidase P from bovine lung: solubilization, properties, and potential role in bradykinin degradation." Mol Cell Biochem 75(2);123-32. PMID: 3627107

Yaron68: Yaron A, Mlynar D (1968). "Aminopeptidase-P." Biochem Biophys Res Commun 32(4);658-63. PMID: 4878817

Yaron70: Yaron, A., Berger, A. (1970). "Aminopeptidase-P." Methods Enzymol.

Yoshimoto88: Yoshimoto T, Murayama N, Honda T, Tone H, Tsuru D (1988). "Cloning and expression of aminopeptidase P gene from Escherichia coli HB101 and characterization of expressed enzyme." J Biochem (Tokyo) 104(1);93-7. PMID: 2851590

Yoshimoto94: Yoshimoto T, Orawski AT, Simmons WH (1994). "Substrate specificity of aminopeptidase P from Escherichia coli: comparison with membrane-bound forms from rat and bovine lung." Arch Biochem Biophys 311(1);28-34. PMID: 8185318


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.