MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: prolyl aminopeptidase

Enzyme Commission Synonyms: proline aminopeptidase, Pro-X aminopeptidase, cytosol aminopeptidase V, proline iminopeptidase

Taxonomic Range: Fungi, Archaea, Metazoa, Viridiplantae, Bacteria

Standard Gibbs Free Energy (ΔrG): 74.62598 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catlayzes Release of N-terminal proline from a peptide.

A Mn2+-requiring enzyme present in the cytosol of mammalian and microbial cells. In contrast to the mammalian form, the bacterial form of the enzyme (type example of peptidase family S33) hydrolyses both polyproline and prolyl-2-naphthylamide. The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC, leucyl aminopeptidase.

Citations: [SARID62, Nordwig73, Turzynski90]

Unification Links: KEGG:R00135

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O32449, UniProt:RELATED-TO:P23974, UniProt:RELATED-TO:P28839, UniProt:RELATED-TO:P42786, UniProt:RELATED-TO:P46542, UniProt:RELATED-TO:P46547, UniProt:RELATED-TO:P47266, UniProt:RELATED-TO:P75092, UniProt:RELATED-TO:P94800, UniProt:RELATED-TO:P96084, UniProt:RELATED-TO:Q9JUV1, UniProt:RELATED-TO:Q48570


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nordwig73: Nordwig A, Mayer H (1973). "The cleavage of prolyl peptides by kidney peptidases. Detection of a new peptidase capable of removing N-terminal proline." Hoppe Seylers Z Physiol Chem 354(4);380-3. PMID: 4803482

SARID62: SARID S, BERGER A, KATCHALSKI E (1962). "Proline iminopeptidase. II. Purification and comparison with iminodipeptidase (prolinase)." J Biol Chem 237;2207-12. PMID: 14497218

Turzynski90: Turzynski A, Mentlein R (1990). "Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase." Eur J Biochem 190(3);509-15. PMID: 2373079

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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