Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc Reaction: 3.4.11.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.11.5

Supersedes EC number: 3.4.1.4

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: prolyl aminopeptidase

Enzyme Commission Synonyms: proline aminopeptidase, Pro-X aminopeptidase, cytosol aminopeptidase V, proline iminopeptidase

Enzyme Commission Summary:
This enzyme catlayzes Release of N-terminal proline from a peptide.

A Mn2+-requiring enzyme present in the cytosol of mammalian and microbial cells. In contrast to the mammalian form, the bacterial form of the enzyme (type example of peptidase family S33) hydrolyses both polyproline and prolyl-2-naphthylamide. The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1, leucyl aminopeptidase.

Citations: [SARID62, Nordwig73, Turzynski90]

Relationship Links: BRENDA:EC:3.4.11.5 , ENZYME:EC:3.4.11.5 , IUBMB-ExplorEnz:EC:3.4.11.5 , UniProt:RELATED-TO:O32449 , UniProt:RELATED-TO:P23974 , UniProt:RELATED-TO:P28839 , UniProt:RELATED-TO:P42786 , UniProt:RELATED-TO:P46542 , UniProt:RELATED-TO:P46547 , UniProt:RELATED-TO:P47266 , UniProt:RELATED-TO:P75092 , UniProt:RELATED-TO:P94800 , UniProt:RELATED-TO:P96084 , UniProt:RELATED-TO:Q9JUV1 , UniProt:RELATED-TO:Q48570


References

Nordwig73: Nordwig A, Mayer H (1973). "The cleavage of prolyl peptides by kidney peptidases. Detection of a new peptidase capable of removing N-terminal proline." Hoppe Seylers Z Physiol Chem 354(4);380-3. PMID: 4803482

SARID62: SARID S, BERGER A, KATCHALSKI E (1962). "Proline iminopeptidase. II. Purification and comparison with iminodipeptidase (prolinase)." J Biol Chem 237;2207-12. PMID: 14497218

Turzynski90: Turzynski A, Mentlein R (1990). "Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase." Eur J Biochem 190(3);509-15. PMID: 2373079


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.