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MetaCyc Reaction: 3.4.11.21

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.4.11.21

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: aspartyl aminopeptidase

Taxonomic Range: Viridiplantae, Metazoa, Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate. Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I

Citations: [Kelly83, Wilk98]

Relationship Links: BRENDA:EC:3.4.11.21, ENZYME:EC:3.4.11.21, IUBMB-ExplorEnz:EC:3.4.11.21


References

Kelly83: Kelly JA, Neidle EL, Neidle A (1983). "An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues." J Neurochem 40(6);1727-34. PMID: 6854330

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wilk98: Wilk S, Wilk E, Magnusson RP (1998). "Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase." J Biol Chem 273(26);15961-70. PMID: 9632644


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc13.