|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 220.127.116.11
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: Xaa-Trp aminopeptidase
Enzyme Commission Synonyms: aminopeptidase W, aminopeptidase X-Trp, X-Trp aminopeptidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -48.12524 [Latendresse13]
Enzyme Commission Summary:
Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on GluTrp, LeuTrp and a number of other dipeptides.
This is a glycoprotein containing Zn2+, from renal and intestinal brush border membranes.
Gee85: Gee NS, Kenny AJ (1985). "Proteins of the kidney microvillar membrane. The 130 kDa protein in pig kidney, recognized by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity." Biochem J 230(3);753-64. PMID: 4062876
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