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MetaCyc Reaction: 3.4.11.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.11.14

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: cytosol alanyl aminopeptidase

Enzyme Commission Synonyms: arylamidase, aminopolypeptidase, thiol-activated aminopeptidase, human liver aminopeptidase, puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, cytosol aminopeptidase III, alanine aminopeptidase

Taxonomic Range: Metazoa , Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): -48.12524 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.

A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family).

Citations: [Starnes74, Kao78, Sidorowicz80]

Relationship Links: BRENDA:EC:3.4.11.14 , ENZYME:EC:3.4.11.14 , IUBMB-ExplorEnz:EC:3.4.11.14


References

Kao78: Kao YJ, Starnes WL, Behal FJ (1978). "Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein." Biochemistry 17(15);2990-4. PMID: 698181

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sidorowicz80: Sidorowicz W, Hsia WC, Maslej-Zownir O, Behal FJ (1980). "Multiple molecular forms of human alanine aminopeptidase: immunochemical properties." Clin Chim Acta 107(3);245-56. PMID: 6108169

Starnes74: Starnes WL, Behal FJ (1974). "A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein." Biochemistry 13(16);3221-7. PMID: 4841062


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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