|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: cytosol alanyl aminopeptidase
Enzyme Commission Synonyms: arylamidase, aminopolypeptidase, thiol-activated aminopeptidase, human liver aminopeptidase, puromycin-sensitive aminopeptidase, soluble alanyl aminopeptidase, cytosol aminopeptidase III, alanine aminopeptidase
Enzyme Commission Summary:
This enzyme catalyzes release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family).
Sidorowicz80: Sidorowicz W, Hsia WC, Maslej-Zownir O, Behal FJ (1980). "Multiple molecular forms of human alanine aminopeptidase: immunochemical properties." Clin Chim Acta 107(3);245-56. PMID: 6108169
Starnes74: Starnes WL, Behal FJ (1974). "A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein." Biochemistry 13(16);3221-7. PMID: 4841062
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