|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: keratan-sulfate endo-1,4-β-galactosidase
Enzyme Commission Synonyms: endo-β-galactosidase, keratan sulfate endogalactosidase, keratanase, keratan-sulfate 1,4-β-D-galactanohydrolase
Enzyme Commission Summary:
This enzyme catalyzes endohydrolysis of (1→4)-β-D-galactosidic linkages in keratan sulfate .
Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to 1,3-N-acetyl-α-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 22.214.171.124, blood-group-substance endo-1,4-β-galactosidase).
Fukuda76: Fukuda MN, Matsumura G (1976). "Endo-beta-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein." J Biol Chem 251(20);6218-25. PMID: 135762
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