MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: keratan-sulfate endo-1,4-β-galactosidase

Enzyme Commission Synonyms: endo-β-galactosidase, keratan sulfate endogalactosidase, keratanase, keratan-sulfate 1,4-β-D-galactanohydrolase

Taxonomic Range: Bacteria

Enzyme Commission Summary:
This enzyme catalyzes endohydrolysis of (1→4)-β-D-galactosidic linkages in keratan sulfate .

Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to 1,3-N-acetyl-α-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC, blood-group-substance endo-1,4-β-galactosidase).

Citations: [Fukuda76]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Revised 26-Jul-2012 by Caspi R , SRI International


Fukuda76: Fukuda MN, Matsumura G (1976). "Endo-beta-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein." J Biol Chem 251(20);6218-25. PMID: 135762

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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