Metabolic Modeling Tutorial
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BioCyc websites down 12/28 - 12/31
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down 12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down 12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down 12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down 12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.1.2.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 3.1.2.14

In Pathway: oleate biosynthesis I (plants)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: oleoyl-[acyl-carrier-protein] hydrolase

Enzyme Commission Synonyms: acyl-[acyl-carrier-protein] hydrolase, acyl-ACP-hydrolase, acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, oleoyl-acyl carrier protein thioesterase, oleoyl-[acyl-carrier-protein] hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 320.50873 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on acyl-carrier-protein thioesters of fatty acids from C12 to C18, but the derivative of oleic acid is hydrolysed much more rapidly than any other compound tested.

Citations: [Ohlrogge78, Shine76]

Relationship Links: BRENDA:EC:3.1.2.14 , ENZYME:EC:3.1.2.14 , IUBMB-ExplorEnz:EC:3.1.2.14 , UniProt:RELATED-TO:O48568 , UniProt:RELATED-TO:O49947 , UniProt:RELATED-TO:P00633 , UniProt:RELATED-TO:P08635 , UniProt:RELATED-TO:P12276 , UniProt:RELATED-TO:P12785 , UniProt:RELATED-TO:P19829 , UniProt:RELATED-TO:P49327 , UniProt:RELATED-TO:Q9SV64 , UniProt:RELATED-TO:Q39402 , UniProt:RELATED-TO:Q41635 , UniProt:RELATED-TO:Q42558 , UniProt:RELATED-TO:Q42561 , UniProt:RELATED-TO:Q43718 , UniProt:RELATED-TO:Q43745

Credits:
Revised 12-Dec-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ohlrogge78: Ohlrogge JB, Shine WE, Stumpf PK (1978). "Fat metabolism in higher plants. Characterization of plant acyl-ACP and acyl-CoA hydrolases." Arch Biochem Biophys 189(2);382-91. PMID: 30409

Shine76: Shine WE, Mancha M, Stumpf PK (1976). "Fat metabolism in higher plants. The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins." Arch Biochem Biophys 172(1);110-6. PMID: 3134


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc12.