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MetaCyc Reaction: 1.2.1.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.2.1.-

Enzymes and Genes:

Bacillus subtilis: branched-chain α-keto acid dehydrogenase complexInferred from experiment: bfmBAB, bfmBAA, bfmBB, pdhD
Homo sapiens: branched-chain α-keto acid dehydrogenase complexTraceable author statement to experimental support: BCKDHB, BCKDHA, DBT, DLD

In Pathway: L-leucine degradation I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Sub-reactions:
4-methyl-2-oxopentanoate + an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+ → a [apo BCAA dehydrogenase E2 protein] N6-S-[3-methylbutanoyl]dihydrolipoyl-L-lysine + CO2,
isovaleryl-CoA + an [apo BCAA dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine = a [apo BCAA dehydrogenase E2 protein] N6-S-[3-methylbutanoyl]dihydrolipoyl-L-lysine + coenzyme A,
an [apo BCAA dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.194031Inferred by computational analysis [Latendresse13]

Summary:
This reaction is the sum of three reactions.

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01651, Rhea:25177


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 6, 2016, biocyc11.