MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: myo-inositol-1,3,4-trisphosphate 5/6-kinaseInferred from experiment: ITPK1
Glycine max: Ins(1,3,4)P3 5-kinaseInferred from experiment
Homo sapiens: inositol-polyphosphate kinase/phosphataseInferred from experiment: ITPK1
Zea mays: myo-inositol polyphosphate kinaseTraceable author statement to experimental support: Ipk

In Pathway: 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inositol-1,3,4-trisphosphate 5/6-kinase

Enzyme Commission Synonyms: Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.305176Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In humans, this enzyme, along with EC, EC and EC is involved in the production of inositol hexakisphosphate (InsP(6)). InsP(6) is involved in many cellular processes, including mRNA export from the nucleus. Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC and EC

Citations: [Wilson96, Verbsky05, Miller05]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03428, Rhea:13253

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miller05: Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase." Mol Cell 18(2);201-12. PMID: 15837423

Verbsky05: Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (2005). "The pathway for the production of inositol hexakisphosphate in human cells." J Biol Chem 280(3);1911-20. PMID: 15531582

Wilson96: Wilson MP, Majerus PW (1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme." J Biol Chem 271(20);11904-10. PMID: 8662638

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC11A.