Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.159

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.159

Enzymes and Genes:
myo-inositol polyphosphate kinase Traceable author statement to experimental support : Ipk ( Zea mays )
inositol-polyphosphate kinase/phosphatase Inferred from experiment : ITPK1 ( Homo sapiens )
Ins(1,3,4)P3 5-kinase Inferred from experiment ( Glycine max )
myo-inositol-1,3,4-trisphosphate 5/6-kinase Inferred from experiment : ITPK1 ( Arabidopsis thaliana col )

In Pathway: 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: inositol-1,3,4-trisphosphate 5/6-kinase

Enzyme Commission Synonyms: Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.305176 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and EC 2.7.1.158 is involved in the production of inositol hexakisphosphate (InsP(6)). InsP(6) is involved in many cellular processes, including mRNA export from the nucleus. Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 2.7.1.151 and EC 2.7.1.158.

Citations: [Wilson96, Verbsky05, Miller05]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03428 , Rhea:13253

Relationship Links: BRENDA:EC:2.7.1.159 , ENZYME:EC:2.7.1.159 , IUBMB-ExplorEnz:EC:2.7.1.159


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miller05: Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase." Mol Cell 18(2);201-12. PMID: 15837423

Verbsky05: Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (2005). "The pathway for the production of inositol hexakisphosphate in human cells." J Biol Chem 280(3);1911-20. PMID: 15531582

Wilson96: Wilson MP, Majerus PW (1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme." J Biol Chem 271(20);11904-10. PMID: 8662638


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC14B.