|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Arabidopsis thaliana col:||myo-inositol-1,3,4-trisphosphate 5/6-kinase: ITPK1|
|Glycine max:||Ins(1,3,4)P3 5-kinase|
|Homo sapiens:||inositol-polyphosphate kinase/phosphatase: ITPK1|
|Zea mays:||myo-inositol polyphosphate kinase: Ipk|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: inositol-1,3,4-trisphosphate 5/6-kinase
Enzyme Commission Synonyms: Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -22.305176 [Latendresse13]
Enzyme Commission Summary:
In humans, this enzyme, along with EC 184.108.40.206, EC 220.127.116.11 and EC 18.104.22.168 is involved in the production of inositol hexakisphosphate (InsP(6)). InsP(6) is involved in many cellular processes, including mRNA export from the nucleus. Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 22.214.171.124 and EC 126.96.36.199.
Miller05: Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase." Mol Cell 18(2);201-12. PMID: 15837423
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