|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Enzymes and Genes:
myo-inositol polyphosphate kinase : Ipk ( Zea mays )
inositol-polyphosphate kinase/phosphatase : ITPK1 ( Homo sapiens )
Ins(1,3,4)P3 5-kinase ( Glycine max )
myo-inositol-1,3,4-trisphosphate 5/6-kinase : ITPK1 ( Arabidopsis thaliana col )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: inositol-1,3,4-trisphosphate 5/6-kinase
Enzyme Commission Synonyms: Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -22.305176 [Latendresse13]
Enzyme Commission Summary:
In humans, this enzyme, along with EC 220.127.116.11, EC 18.104.22.168 and EC 22.214.171.124 is involved in the production of inositol hexakisphosphate (InsP(6)). InsP(6) is involved in many cellular processes, including mRNA export from the nucleus. Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 126.96.36.199 and EC 188.8.131.52.
Miller05: Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase." Mol Cell 18(2);201-12. PMID: 15837423
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493