Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.5.1.42

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.5.1.42

Enzymes and Genes:
digeranylgeranylglyceryl phosphate synthase Inferred from experiment : MTH_1098 ( Methanothermobacter thermautotrophicus Delta H )

In Pathway: CDP-archaeol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: geranylgeranylglycerol-phosphate geranylgeranyltransferase

Enzyme Commission Synonyms: geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, geranylgeranyltransferase II, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.6300049 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [Hemmi04]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and α-glycerophosphate cannot act as prenyl-acceptor substrates [Hemmi04]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [Hemmi04].

Citations: [Morii00]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04520 , Rhea:18109

Relationship Links: BRENDA:EC:2.5.1.42 , ENZYME:EC:2.5.1.42 , IUBMB-ExplorEnz:EC:2.5.1.42

Credits:
Revised 28-Jul-2009 by Caspi R , SRI International


References

Hemmi04: Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T (2004). "(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids." J Biol Chem 279(48);50197-203. PMID: 15356000

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morii00: Morii H, Nishihara M, Koga Y (2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus." J Biol Chem 275(47);36568-74. PMID: 10960477


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14B.