|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Methanothermobacter thermautotrophicus Delta H:||digeranylgeranylglyceryl phosphate synthase: MTH_1098|
In Pathway: CDP-archaeol biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: geranylgeranylglycerol-phosphate geranylgeranyltransferase
Enzyme Commission Synonyms: geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, geranylgeranyltransferase II, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -0.6300049 [Latendresse13]
Enzyme Commission Summary:
This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [Hemmi04]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and α-glycerophosphate cannot act as prenyl-acceptor substrates [Hemmi04]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 22.214.171.1241 (sn-glycerol-1-phosphate dehydrogenase), EC 126.96.36.199 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 188.8.131.52 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine . Belongs in the UbiA prenyltransferase family [Hemmi04].
Hemmi04: Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T (2004). "(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids." J Biol Chem 279(48);50197-203. PMID: 15356000
Morii00: Morii H, Nishihara M, Koga Y (2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus." J Biol Chem 275(47);36568-74. PMID: 10960477
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