MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Saccharomyces cerevisiae: glycerol-3-phosphate acyltransferase: GPT2
glycerol-3-phosphate 1-O-acyltransferase: SCT1

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycerone-phosphate O-acyltransferase

Enzyme Commission Synonyms: dihydroxyacetone phosphate acyltransferase

Taxonomic Range: Metazoa, Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 270.64014Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A membrane protein. Uses CoA derivatives of palmitate, stearate and oleate, with highest activity on palmitoyl-CoA.

Citations: [Hajra68, Declercq84, Ballas81]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a long-chain acyl-CoA + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + coenzyme A] (
i1: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = 1-C16:0-α,ω-dicarboxyl-2-lysophosphatidate + coenzyme A (

i2: 18-hydroxyoleoyl-CoA + sn-glycerol 3-phosphate → 1-[18-hydroxyoleyl]-2-lyso-phosphatidate + coenzyme A (

Unification Links: KEGG:R01013, Rhea:17657

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Ballas81: Ballas LM, Bell RM (1981). "Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles." Biochim Biophys Acta 665(3);586-95. PMID: 6271231

Declercq84: Declercq PE, Haagsman HP, Van Veldhoven P, Debeer LJ, Van Golde LM, Mannaerts GP (1984). "Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis." J Biol Chem 259(14);9064-75. PMID: 6746639

Hajra68: Hajra AK (1968). "Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria." J Biol Chem 243(12);3458-65. PMID: 5656381

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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