Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.42

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.42

Enzymes and Genes:
glycerol-3-phosphate 1-O-acyltransferase : SCT1 ( Saccharomyces cerevisiae )
glycerol-3-phosphate acyltransferase : GPT2 ( Saccharomyces cerevisiae )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycerone-phosphate O-acyltransferase

Enzyme Commission Synonyms: dihydroxyacetone phosphate acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 270.64014 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A membrane protein. Uses CoA derivatives of palmitate, stearate and oleate, with highest activity on palmitoyl-CoA.

Citations: [Hajra68, Declercq84, Ballas81]

Gene-Reaction Schematic: ?

Instance reaction of [a long-chain acyl-CoA + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + coenzyme A] (2.3.1.15):
i1: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = 1-C16:0-α,ω-dicarboxyl-2-lysophosphatidate + coenzyme A (2.3.1.15)

Unification Links: KEGG:R01013 , Rhea:17657

Relationship Links: BRENDA:EC:2.3.1.42 , ENZYME:EC:2.3.1.42 , IUBMB-ExplorEnz:EC:2.3.1.42


References

Ballas81: Ballas LM, Bell RM (1981). "Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles." Biochim Biophys Acta 665(3);586-95. PMID: 6271231

Declercq84: Declercq PE, Haagsman HP, Van Veldhoven P, Debeer LJ, Van Golde LM, Mannaerts GP (1984). "Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis." J Biol Chem 259(14);9064-75. PMID: 6746639

Hajra68: Hajra AK (1968). "Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria." J Biol Chem 243(12);3458-65. PMID: 5656381

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.