|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Saccharomyces cerevisiae :||glycerol-3-phosphate acyltransferase
glycerol-3-phosphate 1-O-acyltransferase : SCT1
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glycerone-phosphate O-acyltransferase
Enzyme Commission Synonyms: dihydroxyacetone phosphate acyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 270.64014 [Latendresse13]
Enzyme Commission Summary:
A membrane protein. Uses CoA derivatives of palmitate, stearate and oleate, with highest activity on palmitoyl-CoA.
Instance reactions of [a long-chain acyl-CoA + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + coenzyme A] (188.8.131.52):
i1: 18-hydroxyoleoyl-CoA + sn-glycerol 3-phosphate → 1-[18-hydroxyoleyl]-2-lyso-phosphatidate + coenzyme A (184.108.40.206)
i2: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = 1-C16:0-α,ω-dicarboxyl-2-lysophosphatidate + coenzyme A (220.127.116.11)
Ballas81: Ballas LM, Bell RM (1981). "Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles." Biochim Biophys Acta 665(3);586-95. PMID: 6271231
Declercq84: Declercq PE, Haagsman HP, Van Veldhoven P, Debeer LJ, Van Golde LM, Mannaerts GP (1984). "Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis." J Biol Chem 259(14);9064-75. PMID: 6746639
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