MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : 1-phosphofructokinase Inferred from experiment : fruK
Lactococcus lactis : 1-phosphofructokinase Inferred from experiment : fruC

In Pathway: fructose degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-phosphofructokinase

Enzyme Commission Synonyms: fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, phosphofructokinase 1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.222412 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ITP, GTP or UTP can replace ATP.

Citations: [Sapico69, Reeves66, Ferenci71, Anderson69b]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02071 , Rhea:14213

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P0AEW9 , UniProt:RELATED-TO:P23354 , UniProt:RELATED-TO:P23386 , UniProt:RELATED-TO:P44330 , UniProt:RELATED-TO:P75038 , UniProt:RELATED-TO:Q48996


Anderson69b: Anderson RL, Wood WA (1969). "Carbohydrate metabolism in microorganisms." Annu Rev Microbiol 23;539-78. PMID: 4900063

Ferenci71: Ferenci T, Kornberg HL (1971). "Pathway of fructose utilization by Escherichia coli." FEBS Lett 13(2);127-130. PMID: 11945648

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Reeves66: Reeves RE, Warren LG, Hsu DS (1966). "1-Phosphofructokinase from an anaerobe." J Biol Chem 241(6);1257-61. PMID: 4222878

Sapico69: Sapico V, Anderson RL (1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties." J Biol Chem 244(22);6280-8. PMID: 4242639

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc13.