Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.56

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.56

Enzymes and Genes:
1-phosphofructokinase Inferred from experiment : fruK ( Escherichia coli K-12 substr. MG1655 )
1-phosphofructokinase Inferred from experiment : fruC ( Lactococcus lactis )

In Pathway: fructose degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-phosphofructokinase

Enzyme Commission Synonyms: fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, phosphofructokinase 1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.222412 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ITP, GTP or UTP can replace ATP.

Citations: [Sapico69, Reeves66, Ferenci71, Anderson69b]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02071 , Rhea:14213

Relationship Links: BRENDA:EC:2.7.1.56 , ENZYME:EC:2.7.1.56 , IUBMB-ExplorEnz:EC:2.7.1.56 , UniProt:RELATED-TO:P0AEW9 , UniProt:RELATED-TO:P23354 , UniProt:RELATED-TO:P23386 , UniProt:RELATED-TO:P44330 , UniProt:RELATED-TO:P75038 , UniProt:RELATED-TO:Q48996


References

Anderson69b: Anderson RL, Wood WA (1969). "Carbohydrate metabolism in microorganisms." Annu Rev Microbiol 23;539-78. PMID: 4900063

Ferenci71: Ferenci T, Kornberg HL (1971). "Pathway of fructose utilization by Escherichia coli." FEBS Lett 13(2);127-130. PMID: 11945648

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Reeves66: Reeves RE, Warren LG, Hsu DS (1966). "1-Phosphofructokinase from an anaerobe." J Biol Chem 241(6);1257-61. PMID: 4222878

Sapico69: Sapico V, Anderson RL (1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties." J Biol Chem 244(22);6280-8. PMID: 4242639


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, BIOCYC13A.