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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: 1-phosphofructokinaseInferred from experiment: fruK
Lactococcus lactis: 1-phosphofructokinaseInferred from experiment: fruC

In Pathway: fructose degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-phosphofructokinase

Enzyme Commission Synonyms: fructose-1-phosphate kinase, 1-phosphofructokinase (phosphorylating), D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, phosphofructokinase 1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -12.222412Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ITP, GTP or UTP can replace ATP.

Citations: [Sapico69, Reeves66, Ferenci71, Anderson69a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02071, Rhea:14213

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P0AEW9, UniProt:RELATED-TO:P23354, UniProt:RELATED-TO:P23386, UniProt:RELATED-TO:P44330, UniProt:RELATED-TO:P75038, UniProt:RELATED-TO:Q48996


Anderson69a: Anderson RL, Wood WA (1969). "Carbohydrate metabolism in microorganisms." Annu Rev Microbiol 23;539-78. PMID: 4900063

Ferenci71: Ferenci T, Kornberg HL (1971). "Pathway of fructose utilization by Escherichia coli." FEBS Lett 13(2);127-130. PMID: 11945648

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Reeves66: Reeves RE, Warren LG, Hsu DS (1966). "1-Phosphofructokinase from an anaerobe." J Biol Chem 241(6);1257-61. PMID: 4222878

Sapico69: Sapico V, Anderson RL (1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties." J Biol Chem 244(22);6280-8. PMID: 4242639

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc14.