|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
saccharopine dehydrogenase ( Bos taurus )
α-aminoadipic semialdehyde synthase, mitochondrial : AASS ( Homo sapiens )
In Pathway: L-lysine degradation XI (mammalian)
Reaction Locations: NIL
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: saccharopine dehydrogenase (NAD+, L-glutamate-forming)
Enzyme Commission Synonyms: dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), saccharopin dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-δ-semialdehyde and glutamate forming), aminoadipic semialdehyde synthase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 5.528778 [Latendresse13]
Enzyme Commission Summary:
The activities of this enzyme along with EC 18.104.22.168, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.
Markovitz84: Markovitz PJ, Chuang DT, Cox RP (1984). "Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities." J Biol Chem 259(19);11643-6. PMID: 6434529
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