MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Bos taurus: saccharopine dehydrogenaseInferred from experiment
Homo sapiens: α-aminoadipic semialdehyde synthase, mitochondrialInferred from experiment: AASS

In Pathway: L-lysine degradation XI (mammalian)

Reaction Locations: NIL

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

Enzyme Commission Synonyms: dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), saccharopin dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-δ-semialdehyde and glutamate forming), aminoadipic semialdehyde synthase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 5.528778Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The activities of this enzyme along with EC, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.

Citations: [Markovitz84, Hutzler68]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02313, Rhea:24520

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Hutzler68: Hutzler J, Dancis J (1968). "Conversion of lysine to saccharopine by human tissues." Biochim Biophys Acta 158(1);62-9. PMID: 4385118

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Markovitz84: Markovitz PJ, Chuang DT, Cox RP (1984). "Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities." J Biol Chem 259(19);11643-6. PMID: 6434529

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC14A.