Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.5.1.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.1.9

Enzymes and Genes:
saccharopine dehydrogenase Inferred from experiment ( Bos taurus )
α-aminoadipic semialdehyde synthase, mitochondrial Inferred from experiment : AASS ( Homo sapiens )

In Pathway: lysine degradation II (mammalian)

Reaction Locations: NIL

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: saccharopine dehydrogenase (NAD+, L-glutamate-forming)

Enzyme Commission Synonyms: dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming), saccharopin dehydrogenase, NAD+ oxidoreductase (L-2-aminoadipic-δ-semialdehyde and glutamate forming), aminoadipic semialdehyde synthase, 6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 5.528778 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.

Citations: [Markovitz84, Hutzler68]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02313 , Rhea:24520

Relationship Links: BRENDA:EC:1.5.1.9 , ENZYME:EC:1.5.1.9 , IUBMB-ExplorEnz:EC:1.5.1.9


References

Hutzler68: Hutzler J, Dancis J (1968). "Conversion of lysine to saccharopine by human tissues." Biochim Biophys Acta 158(1);62-9. PMID: 4385118

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Markovitz84: Markovitz PJ, Chuang DT, Cox RP (1984). "Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities." J Biol Chem 259(19);11643-6. PMID: 6434529


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.