MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

In Pathway: folate transformations I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: methylenetetrahydrofolate dehydrogenase (NAD+)

Enzyme Commission Synonyms: methylenetetrahydrofolate dehydrogenase (NAD+)

Standard Gibbs Free Energy (ΔrG): -10.8819275 kcal/molInferred by computational analysis [Latendresse13]

Citations: [Moore74]

Unification Links: KEGG:R01218, Rhea:22892

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P13995, UniProt:RELATED-TO:P18155, UniProt:RELATED-TO:Q02046, UniProt:RELATED-TO:Q04448, UniProt:RELATED-TO:Q48977


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Moore74: Moore MR, O'Brien WE, Ljungdahl LG (1974). "Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum." J Biol Chem 249(16);5250-3. PMID: 4153026

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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