MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

Enzymes and Genes:

Rattus norvegicus: sterol 26-hydroxylaseInferred from experiment: Cyp27a1, Fdxr

Sub-reaction of:
1.14.15.h: 5β-cholestane-3α,7α,12α-triol + 6 a reduced adrenodoxin + 5 H+ + 3 oxygen → (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate + 6 an oxidized adrenodoxin + 4 H2O

In Pathway: bile acid biosynthesis, neutral pathway

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): -105.649414Inferred by computational analysis [Latendresse13]

Citations: [Masui66]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03506

Relationship Links: UniProt:RELATED-TO:Q54101


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Masui66: Masui T, Herman R, Staple E (1966). "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver." Biochim Biophys Acta 117(1);266-8. PMID: 5914340

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc14.