MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Bombyx mori: acyl-CoA 11-desaturase/conjugaseInferred from experiment: Bmpgdesat1
Trichoplusia ni: acyl-CoA 11-desaturaseInferred from experiment: D11DS

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: acyl-CoA 11-(Z)-desaturase

Enzyme Commission Synonyms: δ11 desaturase, fatty acid δ11-desaturase, TpDESN, Cro-PG, δ11 fatty acid desaturase, Z/E11-desaturase, δ11-palmitoyl-CoA desaturase, Δ11-fatty-acid desaturase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG): -35.015137 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme introduces a cis double bond at position C11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [Tonon04], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [Hao02], while that from the moth Spodoptera littoralis accepts both substrates [Martinez90]. The enzyme contains three histidine boxes that are conserved in all desaturases [Rodriguez92]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.

Citations: [Navarro97]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Hao02: Hao G, O'Connor M, Liu W, Roelofs WL (2002). "Characterization of Z/E11- and Z9-desaturases from the obliquebanded leafroller moth, Choristoneura rosaceana." J Insect Sci 2;26. PMID: 15455060

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Martinez90: Martinez T, Fabrias G, Camps F (1990). "Sex pheromone biosynthetic pathway in Spodoptera littoralis and its activation by a neurohormone." J Biol Chem 265(3);1381-7. PMID: 2295634

Navarro97: Navarro, I., Font, I., Fabrias, G., Camps, F. (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone." J. Am. Chem. Soc. 119:11335-11336.

Rodriguez92: Rodriguez, F., Hallahan, D.L., Pickett, J.A., Camps, F. (1992). "Characterization of the Δ11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera:Noctuidae)." Insect Biochem. Mol. Biol. 22: 143-148.

Tonon04: Tonon T, Harvey D, Qing R, Li Y, Larson TR, Graham IA (2004). "Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonana." FEBS Lett 563(1-3);28-34. PMID: 15063718

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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