|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: Δ11-fatty-acid desaturase
Enzyme Commission Synonyms: δ11 desaturase, fatty acid δ11-desaturase, TpDESN, Cro-PG, δ11 fatty acid desaturase, Z/E11-desaturase, δ11-palmitoyl-CoA desaturase
Enzyme Commission Summary:
In common with front-end desaturases involved in the synthesis of polyunsaturated fatty acids (PUFAs), this membrane-bound enzyme has a cytochrome b5-like domain at the N-terminus and contains three histidine boxes that are critical for desaturase activity. The enzyme from the marine microalga Thalassiosira pseudonana specifically desaturates palmitic acid 16:0 to 16:1-Delta(11) whereas that from the leafroller moth Choristoneura rosaceana desaturates myristic acid 14:0 to 14:1-Delta(11). 16:1-Delta(11) represents an important precursor for pheromone synthesis in insect cells, although its function in microalgae is currently unknown. The enzyme from the Egyptian cotton leafworm Spodoptera littoralis has a preference for palmitoyl-CoA as substrate and for NADH rather than NADPH as reduced acceptor.
Tonon04: Tonon T, Harvey D, Qing R, Li Y, Larson TR, Graham IA (2004). "Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonana." FEBS Lett 563(1-3);28-34. PMID: 15063718
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