MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Methanothermobacter thermautotrophicus Delta H: (NAD(P)-dependent glycerol-1-phosphate dehydrogenaseInferred from experiment: egsA

In Pathway: CDP-archaeol biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: sn-glycerol-1-phosphate dehydrogenase

Enzyme Commission Synonyms: glycerol-1-phosphate dehydrogenase [NAD(P)+], sn-glycerol-1-phosphate:NAD+ oxidoreductase, G-1-P dehydrogenase, Gro1PDH, AraM

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.1193237Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme is responsible for the formation of archaea-specific glycerophosphate and is stereospecifically different from EC

Citations: [Han05, Guldan08, Morii00, Koga98, Nishihara97, Nishihara95]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R05679

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, Rhea:RELATED-TO:21419


Guldan08: Guldan H, Sterner R, Babinger P (2008). "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." Biochemistry 47(28);7376-84. PMID: 18558723

Han05: Han JS, Ishikawa K (2005). "Active site of Zn(2+)-dependent sn-glycerol-1-phosphate dehydrogenase from Aeropyrum pernix K1." Archaea 1(5);311-7. PMID: 15876564

Koga98: Koga Y, Kyuragi T, Nishihara M, Sone N (1998). "Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent." J Mol Evol 46(1);54-63. PMID: 9419225

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morii00: Morii H, Nishihara M, Koga Y (2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus." J Biol Chem 275(47);36568-74. PMID: 10960477

Nishihara95: Nishihara M, Koga Y (1995). "sn-glycerol-1-phosphate dehydrogenase in Methanobacterium thermoautotrophicum: key enzyme in biosynthesis of the enantiomeric glycerophosphate backbone of ether phospholipids of archaebacteria." J Biochem 117(5);933-5. PMID: 8586635

Nishihara97: Nishihara M, Koga Y (1997). "Purification and properties of sn-glycerol-1-phosphate dehydrogenase from Methanobacterium thermoautotrophicum: characterization of the biosynthetic enzyme for the enantiomeric glycerophosphate backbone of ether polar lipids of Archaea." J Biochem 122(3);572-6. PMID: 9348086

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13A.