Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.261

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.261

Enzymes and Genes:
(NAD(P)-dependent glycerol-1-phosphate dehydrogenase Inferred from experiment : egsA ( Methanothermobacter thermautotrophicus Delta H )

In Pathway: CDP-archaeol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: sn-glycerol-1-phosphate dehydrogenase

Enzyme Commission Synonyms: glycerol-1-phosphate dehydrogenase [NAD(P)+], sn-glycerol-1-phosphate:NAD+ oxidoreductase, G-1-P dehydrogenase, Gro1PDH, AraM

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.1193237 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme is responsible for the formation of archaea-specific glycerophosphate and is stereospecifically different from EC 1.1.1.94.

Citations: [Han05a, Guldan08, Morii00, Koga98, Nishihara97, Nishihara95]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.1.1.261 , ENZYME:EC:1.1.1.261 , IUBMB-ExplorEnz:EC:1.1.1.261 , Rhea:RELATED-TO:21419


References

Guldan08: Guldan H, Sterner R, Babinger P (2008). "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." Biochemistry 47(28);7376-84. PMID: 18558723

Han05a: Han JS, Ishikawa K (2005). "Active site of Zn(2+)-dependent sn-glycerol-1-phosphate dehydrogenase from Aeropyrum pernix K1." Archaea 1(5);311-7. PMID: 15876564

Koga98: Koga Y, Kyuragi T, Nishihara M, Sone N (1998). "Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent." J Mol Evol 46(1);54-63. PMID: 9419225

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morii00: Morii H, Nishihara M, Koga Y (2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus." J Biol Chem 275(47);36568-74. PMID: 10960477

Nishihara95: Nishihara M, Koga Y (1995). "sn-glycerol-1-phosphate dehydrogenase in Methanobacterium thermoautotrophicum: key enzyme in biosynthesis of the enantiomeric glycerophosphate backbone of ether phospholipids of archaebacteria." J Biochem 117(5);933-5. PMID: 8586635

Nishihara97: Nishihara M, Koga Y (1997). "Purification and properties of sn-glycerol-1-phosphate dehydrogenase from Methanobacterium thermoautotrophicum: characterization of the biosynthetic enzyme for the enantiomeric glycerophosphate backbone of ether polar lipids of Archaea." J Biochem 122(3);572-6. PMID: 9348086


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.