|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.1681
Enzymes and Genes:
(NAD(P)-dependent glycerol-1-phosphate dehydrogenase : egsA ( Methanothermobacter thermautotrophicus Delta H )
In Pathway: CDP-archaeol biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: sn-glycerol-1-phosphate dehydrogenase
Enzyme Commission Synonyms: glycerol-1-phosphate dehydrogenase [NAD(P)+], sn-glycerol-1-phosphate:NAD+ oxidoreductase, G-1-P dehydrogenase, Gro1PDH, AraM
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -6.1193237 [Latendresse13]
Enzyme Commission Summary:
This enzyme is responsible for the formation of archaea-specific glycerophosphate and is stereospecifically different from EC 22.214.171.124.
Guldan08: Guldan H, Sterner R, Babinger P (2008). "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." Biochemistry 47(28);7376-84. PMID: 18558723
Koga98: Koga Y, Kyuragi T, Nishihara M, Sone N (1998). "Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent." J Mol Evol 46(1);54-63. PMID: 9419225
Morii00: Morii H, Nishihara M, Koga Y (2000). "CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus." J Biol Chem 275(47);36568-74. PMID: 10960477
Nishihara95: Nishihara M, Koga Y (1995). "sn-glycerol-1-phosphate dehydrogenase in Methanobacterium thermoautotrophicum: key enzyme in biosynthesis of the enantiomeric glycerophosphate backbone of ether phospholipids of archaebacteria." J Biochem 117(5);933-5. PMID: 8586635
Nishihara97: Nishihara M, Koga Y (1997). "Purification and properties of sn-glycerol-1-phosphate dehydrogenase from Methanobacterium thermoautotrophicum: characterization of the biosynthetic enzyme for the enantiomeric glycerophosphate backbone of ether polar lipids of Archaea." J Biochem 122(3);572-6. PMID: 9348086
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