Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.181

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.181

Enzymes and Genes:
3β-hydroxy-Δ5-C27 steroid oxidoreductase Inferred from experiment : Hsd3b7 ( Mus musculus )

In Pathway: bile acid biosynthesis, neutral pathway

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: cholest-5-ene-3β,7α-diol 3β-dehydrogenase

Enzyme Commission Synonyms: 3β-hydroxy-δ5-C27-steroid oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.4582367 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Highly specific for 3β-hydroxy-C27-steroids with Δ5-double bond.

Citations: [Wikvall81]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04263 , Rhea:11896

Relationship Links: BRENDA:EC:1.1.1.181 , ENZYME:EC:1.1.1.181 , IUBMB-ExplorEnz:EC:1.1.1.181


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wikvall81: Wikvall K (1981). "Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes." J Biol Chem 256(7);3376-80. PMID: 6937465


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13A.