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MetaCyc Reaction: 1.1.1.181

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.181

Enzymes and Genes:

Mus musculus : 3β-hydroxy-Δ5-C27 steroid oxidoreductase Inferred from experiment : Hsd3b7

In Pathway: bile acid biosynthesis, neutral pathway

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: cholest-5-ene-3β,7α-diol 3β-dehydrogenase

Enzyme Commission Synonyms: 3β-hydroxy-δ5-C27-steroid oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.4582367 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Highly specific for 3β-hydroxy-C27-steroids with Δ5-double bond.

Citations: [Wikvall81]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R04263 , Rhea:11896

Relationship Links: BRENDA:EC:1.1.1.181 , ENZYME:EC:1.1.1.181 , IUBMB-ExplorEnz:EC:1.1.1.181


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wikvall81: Wikvall K (1981). "Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes." J Biol Chem 256(7);3376-80. PMID: 6937465


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon May 25, 2015, biocyc14.