|Gene:||rmpA||Accession Number: G-3185 (MetaCyc)|
Synonyms: HPS, 3-hexulose-6-phosphate synthase
Species: Mycobacterium gastri MN19
Subunit composition of
hexulose-6-phosphate synthase = [RmpA]2
hexulose-6-phosphate synthase subunit = RmpA
Hexulose-6-phosphate synthase (HPS) is one of the key enzymes of the ribulose-5-monophosphate (RuMP) pathway for formaldehyde assimilation. It is also a key enzyme of the related cyclic formaldehyde oxidation (dissimilatory) pathway which is often found in the organisms that poccess the RuMP cycle.
The gene encoding 3-hexulose-6-phosphate synthase is usually present in the same operon as the gene encoding 6-phospho-3-hexuloisomerase, the other key enzyme of the RuMP pathway.
Gene Citations: [Mitsui00]
Molecular Weight of Polypeptide: 24 kD (experimental) [Kato90]
Molecular Weight of Multimer: 43 kD (experimental) [Kato90]
Relationship Links: Entrez-Nucleotide:PART-OF:AB034913
|MultiFun Terms:||metabolism → carbon utilization → carbon compounds|
Enzymatic reaction of: hexulose-6-phosphate synthase
EC Number: 220.127.116.11hexulose 6-phosphate ← D-ribulose 5-phosphate + formaldehyde
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
The reaction is favored in the opposite direction.EDTA [Kato90] Inhibitors (Unknown Mechanism): tiron [Kato90], o-phenanthroline [Kato90]Kinetic Parameters:
pH(opt): 7.5 [Kato90]
Mitsui00: Mitsui R, Sakai Y, Yasueda H, Kato N (2000). "A novel operon encoding formaldehyde fixation: the ribulose monophosphate pathway in the gram-positive facultative methylotrophic bacterium Mycobacterium gastri MB19." J Bacteriol 182(4);944-8. PMID: 10648518
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