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MetaCyc Pathway: tRNA charging
Inferred from experiment

Pathway diagram: tRNA charging

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisAminoacyl-tRNA Charging
Metabolic Clusters

Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Archaea, Bacteria , Eukaryota

This pathway groups together all Escherichia coli tRNA charging reactions.

Unification Links: EcoCyc:TRNA-CHARGING-PWY

References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Abdeljabbar09: Abdeljabbar DM, Klein TJ, Zhang S, Link AJ (2009). "A single genomic copy of an engineered methionyl-tRNA synthetase enables robust incorporation of azidonorleucine into recombinant proteins in E. coli." J Am Chem Soc 131(47);17078-9. PMID: 19894713

Abibi14: Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET (2014). "The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability." J Biol Chem 289(31);21651-62. PMID: 24936059

Ahel02: Ahel I, Stathopoulos C, Ambrogelly A, Sauerwald A, Toogood H, Hartsch T, Soll D (2002). "Cysteine activation is an inherent in vitro property of prolyl-tRNA synthetases." J Biol Chem 277(38);34743-8. PMID: 12130657

Ahel05: Ahel D, Slade D, Mocibob M, Soll D, Weygand-Durasevic I (2005). "Selective inhibition of divergent seryl-tRNA synthetases by serine analogues." FEBS Lett 579(20);4344-8. PMID: 16054140

Airas06: Airas RK (2006). "Analysis of the kinetic mechanism of arginyl-tRNA synthetase." Biochim Biophys Acta 1764(2);307-19. PMID: 16427818

Airas07: Airas RK (2007). "Magnesium dependence of the measured equilibrium constants of aminoacyl-tRNA synthetases." Biophys Chem 131(1-3);29-35. PMID: 17889423

Airas96: Airas RK (1996). "Differences in the magnesium dependences of the class I and class II aminoacyl-tRNA synthetases from Escherichia coli." Eur J Biochem 240(1);223-31. PMID: 8797857

Airas99: Airas RK (1999). "Chloride affects the interaction between tyrosyl-tRNA synthetase and tRNA." Biochim Biophys Acta 1472(1-2);51-61. PMID: 10572925

Akesson78: Akesson B, Lundvik L (1978). "Simultaneous purification and some properties of aspartate: tRNA ligase and seven other amino-acid:tRNA ligases from Escherichia coli." Eur J Biochem 83(1);29-36. PMID: 342244

Aldinger12: Aldinger CA, Leisinger AK, Igloi GL (2012). "The influence of identity elements on the aminoacylation of tRNA(Arg) by plant and Escherichia coli arginyl-tRNA synthetases." FEBS J 279(19);3622-38. PMID: 22831759

Alexander99: Alexander RW, Schimmel P (1999). "Evidence for breaking domain-domain functional communication in a synthetase-tRNA complex." Biochemistry 38(49);16359-65. PMID: 10587461

Andrews85: Andrews D, Trezeguet V, Merle M, Graves PV, Muench KH, Labouesse B (1985). "Tryptophanamide formation by Escherichia coli tryptophanyl-tRNA synthetase." Eur J Biochem 146(1);201-9. PMID: 3881255

Ankilova75: Ankilova VN, Vlassov VV, Knorre DG, Melamed NV, Nuzdihna NA (1975). "Involvement of the D-stem of tRNAPhe (E. coli) in interaction with phenylalanyl-tRNA synthetase as shown by chemical modification." FEBS Lett 60(1);168-71. PMID: 776674

Anselme89: Anselme J, Hartlein M (1989). "Asparaginyl-tRNA synthetase from Escherichia coli has significant sequence homologies with yeast aspartyl-tRNA synthetase." Gene 84(2);481-5. PMID: 2693216

Anselme91: Anselme J, Hartlein M (1991). "Tyr-426 of the Escherichia coli asparaginyl-tRNA synthetase, an amino acid in a C-terminal conserved motif, is involved in ATP binding." FEBS Lett 280(1);163-6. PMID: 2009959

Aoki92: Aoki H, Yaworsky PJ, Patel SD, Margolin-Brzezinski D, Park KS, Ganoza MC (1992). "The asparaginyl-tRNA synthetase gene encodes one of the complementing factors for thermosensitive translation in the Escherichia coli mutant strain, N4316." Eur J Biochem 209(2);511-21. PMID: 1425658

Archibold72: Archibold ER, Williams LS (1972). "Regulation of synthesis of methionyl-, prolyl-, and threonyl-transfer ribonucleic acid synthetases of Escherichia coli." J Bacteriol 109(3);1020-6. PMID: 4551738

Archibold73: Archibold ER, Williams LS (1973). "Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium." J Bacteriol 114(3);1007-13. PMID: 4576394

Archontis01: Archontis G, Simonson T, Karplus M (2001). "Binding free energies and free energy components from molecular dynamics and Poisson-Boltzmann calculations. Application to amino acid recognition by aspartyl-tRNA synthetase." J Mol Biol 306(2);307-27. PMID: 11237602

Archontis01a: Archontis G, Simonson T (2001). "Dielectric relaxation in an enzyme active site: molecular dynamics simulations interpreted with a macroscopic continuum model." J Am Chem Soc 123(44);11047-56. PMID: 11686711

Showing only 20 references. To show more, press the button "Show all references".

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Thu Apr 28, 2016, BIOCYC11A.