This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Degradation/Utilization/Assimilation → Aldehyde Degradation → Lactaldehyde Degradation|
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655 , Salmonella enterica enterica serovar Typhimurium str. LT2
Expected Taxonomic Range: Bacteria
Anaerobically, (S)-lactaldehyde is converted into (S)-propane-1,2-diol by a reversible reaction catalyzed by EC 188.8.131.52, lactaldehyde reductase. Escherichia coli excretes L-1,2-propanediol into the medium, possibly by facilitated diffusion [Zhu89].
Currently two unrelated genes are known to encode such enzymes in different organisms. In Escherichia coli the enzyme is encoded by fucO gene [Chen84a] (known as rhaO in other organisms [Patel08]), in Salmonella enterica enterica serovar Typhimurium str. LT2 it is encoded by the rhaZ gene [Rodionova13].
Superpathways: superpathway of fucose and rhamnose degradation
Variants: L-lactaldehyde degradation (aerobic)
Unification Links: EcoCyc:PWY0-1315
Patel08: Patel EH, Paul LV, Patrick S, Abratt VR (2008). "Rhamnose catabolism in Bacteroides thetaiotaomicron is controlled by the positive transcriptional regulator RhaR." Res Microbiol 159(9-10);678-84. PMID: 18848625
Rodionova13: Rodionova IA, Li X, Thiel V, Stolyar S, Stanton K, Fredrickson JK, Bryant DA, Osterman AL, Best AA, Rodionov DA (2013). "Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria." Front Microbiol 4;407. PMID: 24391637
Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419
Boronat79: Boronat A, Aguilar J (1979). "Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme." J Bacteriol 1979;140(2);320-6. PMID: 40956
Boronat81: Boronat A, Aguilar J (1981). "Experimental evolution of propanediol oxidoreductase in Escherichia coli. Comparative analysis of the wild-type and mutant enzymes." Biochim Biophys Acta 672(1);98-107. PMID: 7011418
Cabiscol90: Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J (1990). "Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli." J Bacteriol 172(9);5514-5. PMID: 2203757
Cabiscol92: Cabiscol E, Badia J, Baldoma L, Hidalgo E, Aguilar J, Ros J (1992). "Inactivation of propanediol oxidoreductase of Escherichia coli by metal-catalyzed oxidation." Biochim Biophys Acta 1118(2);155-60. PMID: 1730033
Cabiscol94: Cabiscol E, Aguilar J, Ros J (1994). "Metal-catalyzed oxidation of Fe2+ dehydrogenases. Consensus target sequence between propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis." J Biol Chem 269(9);6592-7. PMID: 8120011
Chen83: Chen YM, Lin EC, Ros J, Aguilar J (1983). "Use of operon fusions to examine the regulation of the L-1,2-propanediol oxidoreductase gene of the fucose system in Escherichia coli K12." J Gen Microbiol 129(11);3355-62. PMID: 6319547
Chen89: Chen YM, Lu Z, Lin EC (1989). "Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol." J Bacteriol 171(11);6097-105. PMID: 2553671
Cocks74: Cocks GT, Aguilar T, Lin EC (1974). "Evolution of L-1, 2-propanediol catabolism in Escherichia coli by recruitment of enzymes for L-fucose and L-lactate metabolism." J Bacteriol 118(1);83-8. PMID: 4595205
Dellomonaco11: Dellomonaco C, Clomburg JM, Miller EN, Gonzalez R (2011). "Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals." Nature 476(7360);355-9. PMID: 21832992
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Hacking76: Hacking AJ, Lin EC (1976). "Disruption of the fucose pathway as a consequence of genetic adaptation to propanediol as a carbon source in Escherichia coli." J Bacteriol 126(3);1166-72. PMID: 181364
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