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MetaCyc Pathway: L-lactaldehyde degradation (anaerobic)
Inferred from experiment

Enzyme View:

Pathway diagram: L-lactaldehyde degradation (anaerobic)

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/AssimilationAldehyde DegradationLactaldehyde Degradation

Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655, Salmonella enterica enterica serovar Typhimurium str. LT2

Expected Taxonomic Range: Bacteria

(S)-lactaldehyde is one of two products resulting from degradation of the two methylpentoses L-fucose and L-rhamnose, which are metabolized by an analogous series of reactions.

Anaerobically, (S)-lactaldehyde is converted into (S)-propane-1,2-diol by a reversible reaction catalyzed by EC, lactaldehyde reductase. Escherichia coli excretes L-1,2-propanediol into the medium, possibly by facilitated diffusion [Zhu89].

Currently two unrelated genes are known to encode such enzymes in different organisms. In Escherichia coli the enzyme is encoded by fucO gene [Chen84] (known as rhaO in other organisms [Patel08]), in Salmonella enterica enterica serovar Typhimurium str. LT2 it is encoded by the rhaZ gene [Rodionova13].

Superpathways: superpathway of fucose and rhamnose degradation

Variants: L-lactaldehyde degradation (aerobic)

Unification Links: EcoCyc:PWY0-1315

Created 24-Oct-2007 by Keseler I, SRI International


Chen84: Chen YM, Lin EC (1984). "Dual control of a common L-1,2-propanediol oxidoreductase by L-fucose and L-rhamnose in Escherichia coli." J Bacteriol 1984;157(3);828-32. PMID: 6421801

Patel08: Patel EH, Paul LV, Patrick S, Abratt VR (2008). "Rhamnose catabolism in Bacteroides thetaiotaomicron is controlled by the positive transcriptional regulator RhaR." Res Microbiol 159(9-10);678-84. PMID: 18848625

Rodionova13: Rodionova IA, Li X, Thiel V, Stolyar S, Stanton K, Fredrickson JK, Bryant DA, Osterman AL, Best AA, Rodionov DA (2013). "Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria." Front Microbiol 4;407. PMID: 24391637

Zhu89: Zhu Y, Lin EC (1989). "L-1,2-propanediol exits more rapidly than L-lactaldehyde from Escherichia coli." J Bacteriol 1989;171(2);862-7. PMID: 2644239

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419

Boronat79: Boronat A, Aguilar J (1979). "Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme." J Bacteriol 1979;140(2);320-6. PMID: 40956

Boronat81: Boronat A, Aguilar J (1981). "Experimental evolution of propanediol oxidoreductase in Escherichia coli. Comparative analysis of the wild-type and mutant enzymes." Biochim Biophys Acta 672(1);98-107. PMID: 7011418

Boronat81a: Boronat A, Aguilar J (1981). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: differences in induction of propanediol oxidoreductase." J Bacteriol 147(1);181-5. PMID: 7016842

Boronat83: Boronat A, Caballero E, Aguilar J (1983). "Experimental evolution of a metabolic pathway for ethylene glycol utilization by Escherichia coli." J Bacteriol 1983;153(1);134-9. PMID: 6336729

Cabiscol90: Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J (1990). "Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli." J Bacteriol 172(9);5514-5. PMID: 2203757

Cabiscol92: Cabiscol E, Badia J, Baldoma L, Hidalgo E, Aguilar J, Ros J (1992). "Inactivation of propanediol oxidoreductase of Escherichia coli by metal-catalyzed oxidation." Biochim Biophys Acta 1118(2);155-60. PMID: 1730033

Cabiscol94: Cabiscol E, Aguilar J, Ros J (1994). "Metal-catalyzed oxidation of Fe2+ dehydrogenases. Consensus target sequence between propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis." J Biol Chem 269(9);6592-7. PMID: 8120011

Cameron86: Cameron, D.C., Cooney, C.L. (1986). "A novel fermentation: the production of (R)-1,2-propanediol and acetol by Clostridium thermosaccharolyticum." Nature Bio/Technology 4:651-654.

Chen83: Chen YM, Lin EC, Ros J, Aguilar J (1983). "Use of operon fusions to examine the regulation of the L-1,2-propanediol oxidoreductase gene of the fucose system in Escherichia coli K12." J Gen Microbiol 129(11);3355-62. PMID: 6319547

Chen84a: Chen YM, Lin EC (1984). "Post-transcriptional control of L-1,2-propanediol oxidoreductase in the L-fucose pathway of Escherichia coli K-12." J Bacteriol 157(1);341-4. PMID: 6418721

Chen89b: Chen YM, Lu Z, Lin EC (1989). "Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol." J Bacteriol 171(11);6097-105. PMID: 2553671

Cocks74: Cocks GT, Aguilar T, Lin EC (1974). "Evolution of L-1, 2-propanediol catabolism in Escherichia coli by recruitment of enzymes for L-fucose and L-lactate metabolism." J Bacteriol 118(1);83-8. PMID: 4595205

Dellomonaco11: Dellomonaco C, Clomburg JM, Miller EN, Gonzalez R (2011). "Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals." Nature 476(7360);355-9. PMID: 21832992

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

Hacking76: Hacking AJ, Lin EC (1976). "Disruption of the fucose pathway as a consequence of genetic adaptation to propanediol as a carbon source in Escherichia coli." J Bacteriol 126(3);1166-72. PMID: 181364

Hacking78: Hacking AJ, Aguilar J, Lin EC (1978). "Evolution of propanediol utilization in Escherichia coli: mutant with improved substrate-scavenging power." J Bacteriol 136(2);522-30. PMID: 361712

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Showing only 20 references. To show more, press the button "Show all references".

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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