MetaCyc Pathway: botrydial biosynthesis

Pathway diagram: botrydial biosynthesis

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Biosynthesis Secondary Metabolites Biosynthesis Terpenoids Biosynthesis Sesquiterpenoids Biosynthesis

Some taxa known to possess this pathway include ? : Botrytis cinerea

Expected Taxonomic Range: Fungi

Gray mold is a disease caused by the necrotrophic fungus Botrytis cinerea. Several economically important crops and ornamental plants are affected by this disease. Two major phytotoxins are secreted by this filamentous fungus after infection; the sesquiterpene botrydial and the polyketide boticinic acid. These phytotoxins, along with reactive oxygen species, induce oxidative bursts in the host cells, killing the cells. This is followed by a range of fungal degrading exoenzymes that prepare the host tissue for ingestion by the fungus [Choquer07]. In grapes the infection can cause (under specific climatic conditions) the disease "la pourritude noble", otherwise known as 'noble rot'.

This pathway describes the production of botrydial. In microbes, the genes involved in terpene biosynthesis are often present in clusters [Pinedo08]. The BcBot2 gene of Botrytis cinerea is part of cluster that contains five genes, and has been shown to encode a sesquiterpene synthase that produces presilphiperfolan-8β-ol, a precursor of botrydial [Pinedo08].

The virulence factors of Botrytis cinerea are shared with other phytopathogens [Choquer07].

Created 18-Jun-2009 by Pujar A , Boyce Thompson Institute


Choquer07: Choquer M, Fournier E, Kunz C, Levis C, Pradier JM, Simon A, Viaud M (2007). "Botrytis cinerea virulence factors: new insights into a necrotrophic and polyphageous pathogen." FEMS Microbiol Lett 277(1);1-10. PMID: 17986079

Pinedo08: Pinedo C, Wang CM, Pradier JM, Dalmais B, Choquer M, Le Pecheur P, Morgant G, Collado IG, Cane DE, Viaud M (2008). "Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea." ACS Chem Biol 3(12);791-801. PMID: 19035644

Wang09a: Wang CM, Hopson R, Lin X, Cane DE (2009). "Biosynthesis of the Sesquiterpene Botrydial in Botrytis cinerea. Mechanism and Stereochemistry of the Enzymatic Formation of Presilphiperfolan-8beta-ol." J Am Chem Soc 131(24);8360-1. PMID: 19476353

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Apr 27, 2015, biocyc13.