This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Terpenoids Biosynthesis → Sesquiterpenoids Biosynthesis|
Expected Taxonomic Range: cellular organisms
Sesquiterpenes are a large family of C15 isoprenoids, found in bacteria, fungi, insects and plants. They are derived from farnesyl diphosphate (FPP) or nerolidyl diphosphate by the action of enzymes called sesquiterpene synthases. The synthesis of sesquiterpenes from FPP is localized in the cytosol/endoplasmic reticulum boundary. E-bF occurs in a number of plants and is known to play a role in chemical communication. The well studied farnesene in aphids acts as a pheromones and deters predators. The biosynthesis of EbF in Mentha presents the possibility of engineering the EbS gene into other plants. The production of aphid deflecting farnesene products would provide the much needed defence against aphid infestation of plants [Prosser06].
The cis-calamenene sesquiterpenoids are found in the foliage of Cupressus bakeri as natural products. They are also isolated from Madagascan shrub Tarenna madagascariensis (Rubiaceae) [Salmoun07].
Prosser06: Prosser IM, Adams RJ, Beale MH, Hawkins ND, Phillips AL, Pickett JA, Field LM (2006). "Cloning and functional characterisation of a cis-muuroladiene synthase from black peppermint (Menthaxpiperita) and direct evidence for a chemotype unable to synthesise farnesene." Phytochemistry 67(15);1564-71. PMID: 16083926
Salmoun07: Salmoun M, Braekman JC, Ranarivelo Y, Rasamoelisendra R, Ralambomanana D, Dewelle J, Darro F, Kiss R (2007). "New calamenene sesquiterpenes from Tarenna madagascariensis." Nat Prod Res 21(2);111-20. PMID: 17365697
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