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MetaCyc Pathway: GDP-L-fucose biosynthesis II (from L-fucose)
Author statementInferred from experiment

Enzyme View:

Pathway diagram: GDP-L-fucose biosynthesis II (from L-fucose)

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: GDP-L-fucose biosynthesis (salvage pathway)

Superclasses: BiosynthesisCarbohydrates BiosynthesisSugars BiosynthesisSugar Nucleotides BiosynthesisGDP-sugar Biosynthesis

Some taxa known to possess this pathway include : Acer pseudoplatanus, Arabidopsis thaliana col, Homo sapiens, Sus scrofa

Expected Taxonomic Range: Eukaryota

General Background

L-Fucose is an important monosaccharide found in a diverse array of organisms. It is a carbohydrate component of bacterial lipopolysaccharides, mammalian and plant glycoproteins (such as the human antigenic glycoproteins or glycolipids of erythrocyte membranes) and various plant cell wall polysaccharides. It is found in xyloglucans and rhamnogalacturonans I and II. Fucosylation is performed by fucosyltransferases which require the activated form GDP-L-fucose (GDP-Fuc) as the donor substrate.

The formation of UDP-Fuc occurs via two routes: a) a salvage pathway leading to the formation of UDP-Fuc from free L-fucose (this pathway), and b) a de novo synthesis route from GDP-D-mannose ( GDP-L-fucose biosynthesis I (from GDP-D-mannose)).

In plants, biosynthesis of GDP-L-fucose is thought to occur mainly through de novo synthesis. The primary role of the sugar salvage pathways is presumed to be in the recycling of sugars derived from the turnover of macromolecules such as polysaccharides, galactolipids and proteoglycans, which have sugar components. Although the presence of GDP-L-fucose pyrophosphorylase activity in sycamore cell cultures and corn roots has been suggested [Roberts68, Green78] no enzyme of this pathway have yet been described in plants.

Unification Links: AraCyc:PWY-6


Feingold82: Feingold D.S. (1982). "Aldo (and keto) hexoses and uronic acids." Plant Carbohydrates I - Intracellular carbohydrates, Encyclopedia of Plant Physiology, Vol 13A, Eds Loewus and Tanner, pp3-76.

Green78: Green JR, Northcote DH (1978). "The structure and function of glycoproteins synthesized during slime-polysaccharide production by membranes of the root-cap cells of maize (Zea mays)." Biochem J 170(3);599-608. PMID: 646802

Roberts68: Roberts RM (1968). "The metabolism of L-fucose by sycamore (Acer pseudoplatanus L.) cell cultures." Arch Biochem Biophys 128(3);818-20. PMID: 5704313

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Ishihara68: Ishihara H, Heath EC (1968). "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine liver." J Biol Chem 243(6);1110-5. PMID: 5646162

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Park98: Park SH, Pastuszak I, Drake R, Elbein AD (1998). "Purification to apparent homogeneity and properties of pig kidney L-fucose kinase." J Biol Chem 273(10);5685-91. PMID: 9488699

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc14.