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MetaCyc Pathway: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
Traceable author statement to experimental support

Enzyme View:

Pathway diagram: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisCofactors, Prosthetic Groups, Electron Carriers BiosynthesisNAD MetabolismNAD Biosynthesis

Some taxa known to possess this pathway include : Actinobacteria , Cytophaga hutchinsonii, Gemmata sp. Wa1-1, Homo sapiens, Oryza sativa, Polaribacter filamentus, Saccharomyces cerevisiae, Streptomyces antibioticus, Xanthomonas arboricola, Xanthomonas axonopodis

Expected Taxonomic Range: Bacteria , Eukaryota

This is the later portion of the pathway used in eukaryotes for de novo biosynthesis of NAD, which starts with the amino acid L-tryptophan. For the full pathway and more information, please see NAD biosynthesis II (from tryptophan).

Superpathways: NAD biosynthesis II (from tryptophan), superpathway of NAD biosynthesis in eukaryotes

Variants: NAD biosynthesis I (from aspartate), NAD biosynthesis III, NAD salvage pathway I, NAD salvage pathway II, NAD salvage pathway III

Created 07-Sep-2007 by Caspi R, SRI International


Panozzo02: Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ (2002). "Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae." FEBS Lett 517(1-3);97-102. PMID: 12062417

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Anderson02: Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA (2002). "Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels." J Biol Chem 277(21);18881-90. PMID: 11884393

Balducci92: Balducci E, Emanuelli M, Magni G, Raffaelli N, Ruggieri S, Vita A, Natalini P (1992). "Nuclear matrix-associated NMN adenylyltransferase activity in human placenta." Biochem Biophys Res Commun 189(3);1275-9. PMID: 1282798

Berger05: Berger F, Lau C, Dahlmann M, Ziegler M (2005). "Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms." J Biol Chem 280(43);36334-41. PMID: 16118205

Bhatia96: Bhatia R, Calvo KC (1996). "The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli." Arch Biochem Biophys 325(2);270-8. PMID: 8561507

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Brown90: Brown OR, Seither RL (1990). "Paraquat toxicity and pyridine nucleotide coenzyme synthesis: a data correction." Free Radic Biol Med 8(2);113-6. PMID: 2139629

Dahmen67: Dahmen W, Webb B, Preiss J (1967). "The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast." Arch Biochem Biophys 1967;120(2);440-50. PMID: 4291828

Emanuelli01: Emanuelli M, Carnevali F, Saccucci F, Pierella F, Amici A, Raffaelli N, Magni G (2001). "Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase." J Biol Chem 276(1);406-12. PMID: 11027696

Emanuelli99: Emanuelli M, Carnevali F, Lorenzi M, Raffaelli N, Amici A, Ruggieri S, Magni G (1999). "Identification and characterization of YLR328W, the Saccharomyces cerevisiae structural gene encoding NMN adenylyltransferase. Expression and characterization of the recombinant enzyme." FEBS Lett 455(1-2);13-7. PMID: 10428462

Fukuoka98: Fukuoka SI, Nyaruhucha CM, Shibata K (1998). "Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase." Biochim Biophys Acta 1395(2);192-201. PMID: 9473669

Fukuoka99: Fukuoka S, Shibata K (1999). "Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase." Adv Exp Med Biol 467;611-4. PMID: 10721107

Garavaglia02: Garavaglia S, D'Angelo I, Emanuelli M, Carnevali F, Pierella F, Magni G, Rizzi M (2002). "Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis." J Biol Chem 277(10);8524-30. PMID: 11751893

Gardner90: Gardner PR, Fridovich I (1990). "Quinolinate phosphoribosyl transferase is not the oxygen-sensitive site of nicotinamide adenine dinucleotide biosynthesis." Free Radic Biol Med 8(2);117-9. PMID: 2139630

Hara03: Hara N, Yamada K, Terashima M, Osago H, Shimoyama M, Tsuchiya M (2003). "Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency." J Biol Chem 278(13);10914-21. PMID: 12547821

Imsande61: Imsande J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli." J Biol Chem 1961;236(5):1494-1497. PMID: 13717628

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lau09: Lau C, Niere M, Ziegler M (2009). "The NMN/NaMN adenylyltransferase (NMNAT) protein family." Front Biosci (Landmark Ed) 14;410-31. PMID: 19273075

Liu07b: Liu H, Woznica K, Catton G, Crawford A, Botting N, Naismith JH (2007). "Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens." J Mol Biol 373(3);755-63. PMID: 17868694

Mann74: Mann DF, Byerrum RU (1974). "Quinolinic acid phosphoribosyltransferase from castor bean endosperm. I. Purification and characterization." J Biol Chem 249(21);6817-23. PMID: 4422841

Mehl00: Mehl RA, Kinsland C, Begley TP (2000). "Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene." J Bacteriol 2000;182(15);4372-4. PMID: 10894752

Showing only 20 references. To show more, press the button "Show all references".

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc14.