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MetaCyc Pathway: L-lysine degradation IX
Inferred from experiment

Pathway diagram: L-lysine degradation IX

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/AssimilationAmino Acids DegradationProteinogenic Amino Acids DegradationL-lysine Degradation

Some taxa known to possess this pathway include : Meyerozyma guilliermondii

Expected Taxonomic Range: Fungi

Several different enzymes convert L-lysine to (S)-2-amino-6-oxohexanoate, as shown in MetaCyc pathways L-lysine degradation VI, L-lysine degradation VIII and L-lysine degradation IX.

(S)-2-amino-6-oxohexanoate spontaneously cyclizes in solution to form 1-piperideine 6-carboxylate [Misono82].

A novel, inducible L-lysine:pyruvate aminotransferase has been characterized in the industrially relevant yeast Meyerozyma guilliermondii (anamorph Candida guilliermondii). This enzyme specifically uses L-lysine as amino group donor and pyruvate as amino group acceptor to produce (S)-2-amino-6-oxohexanoate and L-alanine. The organism is able to use L-lysine as a sole nitrogen source, but not as a sole carbon source. When Meyerozyma guilliermondii is grown with ammonia as the sole nitrogen source the enzyme is present in very low amounts, but it increases over 100-fold when cells are grown with L-lysine as the sole nitrogen source.

The high inducibility of L-lysine:pyruvate:aminotransferase by L-lysine, the absence of any other lysine-degrading enzyme activities in this organism, and the isolation of regulatory mutants of this enzyme that are unable to use L-lysine as sole nitrogen source, provides evidence that L-lysine:pyruvate:aminotransferase plays an important role as the first step in lysine catabolism in Meyerozyma guilliermondii [Schmidt87, Schmidt88].

Further metabolism of 1-piperideine 6-carboxylate has not been described in Meyerozyma guilliermondii, although this compound is metabolized via L-2-aminoadipate to glutarate by Pseudomonas putida (see MetaCyc pathway L-lysine degradation V).

Superpathways: superpathway of L-lysine degradation

Variants: L-lysine degradation I, L-lysine degradation II (L-pipecolate pathway), L-lysine degradation III, L-lysine degradation IV, L-lysine degradation V, L-lysine degradation VI, L-lysine degradation VII, L-lysine degradation VIII, L-lysine degradation X, L-lysine degradation XI (mammalian), L-lysine fermentation to acetate and butanoate

Created 11-Sep-2006 by Fulcher CA, SRI International


Misono82: Misono H, Nagasaki S (1982). "Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens." J Bacteriol 150(1);398-401. PMID: 6801024

Schmidt87: Schmidt H., Bode R., Birnbaum D. (1987). "Lysine degradation in Pichia guilliermondii: Characterization of a novel enzyme, L-lysine:pyruvate aminotransferase." J. Basic Microbiol. 27:595-601.

Schmidt88: Schmidt H., Bode R.., Birnbaum D. (1988). "A novel enzyme, L-lysine:pyruvate aminotransferase, catalyses the first step of lysine catabolism in Pichia guilliermondii." FEMS Microbiology Letters 49:203-206.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc14.