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MetaCyc Pathway: glutaryl-CoA degradation
Inferred from experiment

Enzyme View:

Pathway diagram: glutaryl-CoA degradation

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/AssimilationCarboxylates Degradation

Some taxa known to possess this pathway include : Homo sapiens, Pseudomonas putida, Pseudomonas Sp. K172, Pseudomonas sp. KB 740, Rhodopseudomonas palustris, Saccharomyces cerevisiae, Syntrophus aciditrophicus, Syntrophus buswellii, Syntrophus gentianae, Thauera aromatica

Expected Taxonomic Range: Bacteria , Fungi, Metazoa

Glutaryl-CoA is a common intermediate in the degradation of many different compounds, such as benzoate and benzoyl-CoA, L-lysine, L-tryptophan and many more. In this pathway glutaryl-CoA is degraded by β-oxidation to 2 molecules of acetyl-CoA and one molecule of CO2.

This pathway can operate under both anaerobic [Koch93] and aerobic conditions [Westover01], although the enzymes catalyzing it may be specialized for either aerobic or anaerobic operation.

Superpathways: toluene degradation VI (anaerobic), L-tryptophan degradation III (eukaryotic), benzoate fermentation (to acetate and cyclohexane carboxylate)

Created 11-May-2006 by Caspi R, SRI International


Koch93: Koch J, Eisenreich W, Bacher A, Fuchs G (1993). "Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism." Eur J Biochem 211(3);649-61. PMID: 8436125

Westover01: Westover JB, Goodman SI, Frerman FE (2001). "Binding, hydration, and decarboxylation of the reaction intermediate glutaconyl-coenzyme A by human glutaryl-CoA dehydrogenase." Biochemistry 40(46);14106-14. PMID: 11705404

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Agnihotri03: Agnihotri G, Liu HW (2003). "Enoyl-CoA hydratase. reaction, mechanism, and inhibition." Bioorg Med Chem 11(1);9-20. PMID: 12467702

Alber06: Alber BE, Spanheimer R, Ebenau-Jehle C, Fuchs G (2006). "Study of an alternate glyoxylate cycle for acetate assimilation by Rhodobacter sphaeroides." Mol Microbiol 61(2);297-309. PMID: 16856937

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Barker82: Barker HA, Kahn JM, Hedrick L (1982). "Pathway of lysine degradation in Fusobacterium nucleatum." J Bacteriol 152(1);201-7. PMID: 6811551

Beatrix90: Beatrix B, Bendrat K, Rospert S, Buckel W (1990). "The biotin-dependent sodium ion pump glutaconyl-CoA decarboxylase from Fusobacterium nucleatum (subsp. nucleatum). Comparison with the glutaconyl-CoA decarboxylases from gram-positive bacteria." Arch Microbiol 154(4);362-9. PMID: 2244788

Beckman91: Beckman DL, Kranz RG (1991). "A bacterial homolog to the mitochondrial enoyl-CoA hydratase." Gene 107(1);171-2. PMID: 1743516

Bendrat93: Bendrat K, Buckel W (1993). "Cloning, sequencing and expression of the gene encoding the carboxytransferase subunit of the biotin-dependent Na+ pump glutaconyl-CoA decarboxylase from Acidaminococcus fermentans in Escherichia coli." Eur J Biochem 1993;211(3);697-702. PMID: 8382157

Bennett84: Bennett MJ, Hosking GP, Smith MF, Gray RG, Middleton B (1984). "Biochemical investigations on a patient with a defect in cytosolic acetoacetyl-CoA thiolase, associated with mental retardation." J Inherit Metab Dis 7(3);125-8. PMID: 6150136

Berg07: Berg IA, Kockelkorn D, Buckel W, Fuchs G (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea." Science 318(5857);1782-6. PMID: 18079405

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Buckel83: Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria." Eur J Biochem 1983;136(2);427-34. PMID: 6628393

Chen91: Chen GL, Balfe A, Erwa W, Hoefler G, Gaertner J, Aikawa J, Chen WW (1991). "Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro." Biochem Biophys Res Commun 178(3);1084-91. PMID: 1651711

Chen94a: Chen D, Swenson RP (1994). "Cloning, sequence analysis, and expression of the genes encoding the two subunits of the methylotrophic bacterium W3A1 electron transfer flavoprotein." J Biol Chem 269(51);32120-30. PMID: 7798207

Colby92: Colby GD, Chen JS (1992). "Purification and properties of 3-hydroxybutyryl-coenzyme A dehydrogenase from Clostridium beijerinckii ("Clostridium butylicum") NRRL B593." Appl Environ Microbiol 58(10);3297-302. PMID: 1444364

Conrad74: Conrad RS, Massey LK, Sokatch JR (1974). "D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida." J Bacteriol 118(1);103-11. PMID: 4150713

Daum98: Daum G, Lees ND, Bard M, Dickson R (1998). "Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae." Yeast 1998;14(16);1471-510. PMID: 9885152

Dekishima11: Dekishima Y, Lan EI, Shen CR, Cho KM, Liao JC (2011). "Extending Carbon Chain Length of 1-Butanol Pathway for 1-Hexanol Synthesis from Glucose by Engineered Escherichia coli." J Am Chem Soc 133(30);11399-401. PMID: 21707101

Duncombe76: Duncombe GR, Frerman FE (1976). "Molecular and catalytic properties of the acetoacetyl-coenzyme A thiolase of Escherichia coli." Arch Biochem Biophys 1976;176(1);159-70. PMID: 9904

Ferdinandusse04: Ferdinandusse S, Denis S, Van Roermund CW, Wanders RJ, Dacremont G (2004). "Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids." J Lipid Res 45(6);1104-11. PMID: 15060085

Fiedler02: Fiedler S, Steinbuchel A, Rehm BH (2002). "The role of the fatty acid beta-oxidation multienzyme complex from Pseudomonas oleovorans in polyhydroxyalkanoate biosynthesis: molecular characterization of the fadBA operon from P. oleovorans and of the enoyl-CoA hydratase genes phaJ from P. oleovorans and Pseudomonas putida." Arch Microbiol 178(2);149-60. PMID: 12115060

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Apr 29, 2016, BIOCYC11A.