If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: fucose and rhamnose catabolism
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655
Expected Taxonomic Range: Bacteria
In Escherichia coli, L-fucose and L-rhamnose are metabolized through parallel pathways. The pathways converge after their corresponding aldolase reactions yielding the same products: glycerone phosphate (which enters central metabolism directly via the glycolysis pathway) and (S)-lactaldehyde. Under aerobic conditions, (S)-lactaldehyde is oxidized in two steps to pyruvate, thereby channeling all the carbons from fucose or rhamnose into central metabolic pathways. Under anaerobic conditions, (S)-lactaldehyde is reduced to (S)-propane-1,2-diol, which is secreted into the environment.
Review: Mayer, C. and W. Boos, Hexose/Pentose and Hexitol/Pentitol Metabolism, EcoSal Module 3.4.1 [ECOSAL].
Unification Links: EcoCyc:FUC-RHAMCAT-PWY
Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419
Badia91: Badia J, Gimenez R, Baldoma L, Barnes E, Fessner WD, Aguilar J (1991). "L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose." J Bacteriol 1991;173(16);5144-50. PMID: 1650346
Baldoma88: Baldoma L, Aguilar J (1988). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation." J Bacteriol 170(1);416-21. PMID: 3275622
Boronat79: Boronat A, Aguilar J (1979). "Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme." J Bacteriol 1979;140(2);320-6. PMID: 40956
Boronat81: Boronat A, Aguilar J (1981). "Experimental evolution of propanediol oxidoreductase in Escherichia coli. Comparative analysis of the wild-type and mutant enzymes." Biochim Biophys Acta 672(1);98-107. PMID: 7011418
Caballero83: Caballero E, Baldoma L, Ros J, Boronat A, Aguilar J (1983). "Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli." J Biol Chem 1983;258(12);7788-92. PMID: 6345530
Cabiscol90: Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J (1990). "Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli." J Bacteriol 172(9);5514-5. PMID: 2203757
Cabiscol92: Cabiscol E, Badia J, Baldoma L, Hidalgo E, Aguilar J, Ros J (1992). "Inactivation of propanediol oxidoreductase of Escherichia coli by metal-catalyzed oxidation." Biochim Biophys Acta 1118(2);155-60. PMID: 1730033
Cabiscol94: Cabiscol E, Aguilar J, Ros J (1994). "Metal-catalyzed oxidation of Fe2+ dehydrogenases. Consensus target sequence between propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis." J Biol Chem 269(9);6592-7. PMID: 8120011
Chang04: Chang DE, Smalley DJ, Tucker DL, Leatham MP, Norris WE, Stevenson SJ, Anderson AB, Grissom JE, Laux DC, Cohen PS, Conway T (2004). "Carbon nutrition of Escherichia coli in the mouse intestine." Proc Natl Acad Sci U S A 101(19);7427-32. PMID: 15123798
Chen83: Chen YM, Lin EC, Ros J, Aguilar J (1983). "Use of operon fusions to examine the regulation of the L-1,2-propanediol oxidoreductase gene of the fucose system in Escherichia coli K12." J Gen Microbiol 129(11);3355-62. PMID: 6319547
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