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MetaCyc Pathway: superpathway of fucose and rhamnose degradation
Traceable author statement to experimental support

Pathway diagram: superpathway of fucose and rhamnose degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: fucose and rhamnose catabolism

Superclasses: Superpathways

Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Bacteria

In Escherichia coli, L-fucose and L-rhamnose are metabolized through parallel pathways. The pathways converge after their corresponding aldolase reactions yielding the same products: glycerone phosphate (which enters central metabolism directly via the glycolysis pathway) and (S)-lactaldehyde. Under aerobic conditions, (S)-lactaldehyde is oxidized in two steps to pyruvate, thereby channeling all the carbons from fucose or rhamnose into central metabolic pathways. Under anaerobic conditions, (S)-lactaldehyde is reduced to (S)-propane-1,2-diol, which is secreted into the environment.

Review: Mayer, C. and W. Boos, Hexose/Pentose and Hexitol/Pentitol Metabolism, EcoSal Module 3.4.1 [ECOSAL].

Subpathways: L-lactaldehyde degradation (anaerobic), L-lactaldehyde degradation (aerobic), fucose degradation, L-rhamnose degradation I

Unification Links: EcoCyc:FUC-RHAMCAT-PWY


ECOSAL: EcoSal "Escherichia coli and Salmonella: Cellular and Molecular Biology." Online edition.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Akhy84: Akhy MT, Brown CM, Old DC (1984). "L-Rhamnose utilisation in Salmonella typhimurium." J Appl Bacteriol 56(2);269-74. PMID: 6373710

Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419

Badia89: Badia J, Baldoma L, Aguilar J, Boronat A (1989). "Identification of the rhaA, rhaB and rhaD gene products from Escherichia coli K-12." FEMS Microbiol Lett 53(3);253-7. PMID: 2558952

Badia91: Badia J, Gimenez R, Baldoma L, Barnes E, Fessner WD, Aguilar J (1991). "L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose." J Bacteriol 1991;173(16);5144-50. PMID: 1650346

Baldoma87: Baldoma L, Aguilar J (1987). "Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12." J Biol Chem 262(29);13991-6. PMID: 3308886

Baldoma88: Baldoma L, Aguilar J (1988). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation." J Bacteriol 170(1);416-21. PMID: 3275622

Boronat79: Boronat A, Aguilar J (1979). "Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme." J Bacteriol 1979;140(2);320-6. PMID: 40956

Boronat81: Boronat A, Aguilar J (1981). "Experimental evolution of propanediol oxidoreductase in Escherichia coli. Comparative analysis of the wild-type and mutant enzymes." Biochim Biophys Acta 672(1);98-107. PMID: 7011418

Boronat81a: Boronat A, Aguilar J (1981). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: differences in induction of propanediol oxidoreductase." J Bacteriol 147(1);181-5. PMID: 7016842

Boronat83: Boronat A, Caballero E, Aguilar J (1983). "Experimental evolution of a metabolic pathway for ethylene glycol utilization by Escherichia coli." J Bacteriol 1983;153(1);134-9. PMID: 6336729

Boulter73: Boulter JR, Gielow WO (1973). "Properties of D-arabinose isomerase purified from two strains of Escherichia coli." J Bacteriol 113(2);687-96. PMID: 4632320

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Caballero83: Caballero E, Baldoma L, Ros J, Boronat A, Aguilar J (1983). "Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli." J Biol Chem 1983;258(12);7788-92. PMID: 6345530

Cabiscol90: Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J (1990). "Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli." J Bacteriol 172(9);5514-5. PMID: 2203757

Cabiscol92: Cabiscol E, Badia J, Baldoma L, Hidalgo E, Aguilar J, Ros J (1992). "Inactivation of propanediol oxidoreductase of Escherichia coli by metal-catalyzed oxidation." Biochim Biophys Acta 1118(2);155-60. PMID: 1730033

Cabiscol94: Cabiscol E, Aguilar J, Ros J (1994). "Metal-catalyzed oxidation of Fe2+ dehydrogenases. Consensus target sequence between propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis." J Biol Chem 269(9);6592-7. PMID: 8120011

Cameron86: Cameron, D.C., Cooney, C.L. (1986). "A novel fermentation: the production of (R)-1,2-propanediol and acetol by Clostridium thermosaccharolyticum." Nature Bio/Technology 4:651-654.

Chang04: Chang DE, Smalley DJ, Tucker DL, Leatham MP, Norris WE, Stevenson SJ, Anderson AB, Grissom JE, Laux DC, Cohen PS, Conway T (2004). "Carbon nutrition of Escherichia coli in the mouse intestine." Proc Natl Acad Sci U S A 101(19);7427-32. PMID: 15123798

Chen83: Chen YM, Lin EC, Ros J, Aguilar J (1983). "Use of operon fusions to examine the regulation of the L-1,2-propanediol oxidoreductase gene of the fucose system in Escherichia coli K12." J Gen Microbiol 129(11);3355-62. PMID: 6319547

Chen84: Chen YM, Lin EC (1984). "Post-transcriptional control of L-1,2-propanediol oxidoreductase in the L-fucose pathway of Escherichia coli K-12." J Bacteriol 157(1);341-4. PMID: 6418721

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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