Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Pathway: superpathway of fucose and rhamnose degradation

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: fucose and rhamnose catabolism

Superclasses: Superpathways

Some taxa known to possess this pathway include ? : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Bacteria

Summary:
In Escherichia coli, L-fucose and L-rhamnose are metabolized through parallel pathways. The pathways converge after their corresponding aldolase reactions yielding the same products: dihydroxyacetone phosphate (which enters central metabolism directly via the glycolysis pathway) and (S)-lactaldehyde. Under aerobic conditions, (S)-lactaldehyde is oxidized in two steps to pyruvate, thereby channeling all the carbons from fucose or rhamnose into central metabolic pathways. Under anaerobic conditions, (S)-lactaldehyde is reduced to (S)-propane-1,2-diol, which is secreted into the environment.

Review: Mayer, C. and W. Boos, Hexose/Pentose and Hexitol/Pentitol Metabolism, EcoSal Module 3.4.1 [ECOSAL].

Subpathways: L-lactaldehyde degradation (anaerobic) , L-lactaldehyde degradation (aerobic) , fucose degradation , L-rhamnose degradation I

Unification Links: EcoCyc:FUC-RHAMCAT-PWY


References

ECOSAL: EcoSal "Escherichia coli and Salmonella: Cellular and Molecular Biology." Online edition.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Akhy84: Akhy MT, Brown CM, Old DC (1984). "L-Rhamnose utilisation in Salmonella typhimurium." J Appl Bacteriol 56(2);269-74. PMID: 6373710

Autieri07: Autieri SM, Lins JJ, Leatham MP, Laux DC, Conway T, Cohen PS (2007). "L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium." Infect Immun 75(11);5465-75. PMID: 17709419

Badia89: Badia J, Baldoma L, Aguilar J, Boronat A (1989). "Identification of the rhaA, rhaB and rhaD gene products from Escherichia coli K-12." FEMS Microbiol Lett 53(3);253-7. PMID: 2558952

Badia91: Badia J, Gimenez R, Baldoma L, Barnes E, Fessner WD, Aguilar J (1991). "L-lyxose metabolism employs the L-rhamnose pathway in mutant cells of Escherichia coli adapted to grow on L-lyxose." J Bacteriol 1991;173(16);5144-50. PMID: 1650346

Baldoma87: Baldoma L, Aguilar J (1987). "Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12." J Biol Chem 262(29);13991-6. PMID: 3308886

Baldoma88: Baldoma L, Aguilar J (1988). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: aerobic-anaerobic regulation of L-lactaldehyde dissimilation." J Bacteriol 170(1);416-21. PMID: 3275622

Boronat79: Boronat A, Aguilar J (1979). "Rhamnose-induced propanediol oxidoreductase in Escherichia coli: purification, properties, and comparison with the fucose-induced enzyme." J Bacteriol 1979;140(2);320-6. PMID: 40956

Boronat81: Boronat A, Aguilar J (1981). "Metabolism of L-fucose and L-rhamnose in Escherichia coli: differences in induction of propanediol oxidoreductase." J Bacteriol 147(1);181-5. PMID: 7016842

Boronat81a: Boronat A, Aguilar J (1981). "Experimental evolution of propanediol oxidoreductase in Escherichia coli. Comparative analysis of the wild-type and mutant enzymes." Biochim Biophys Acta 672(1);98-107. PMID: 7011418

Boronat83: Boronat A, Caballero E, Aguilar J (1983). "Experimental evolution of a metabolic pathway for ethylene glycol utilization by Escherichia coli." J Bacteriol 1983;153(1);134-9. PMID: 6336729

Boulter73: Boulter JR, Gielow WO (1973). "Properties of D-arabinose isomerase purified from two strains of Escherichia coli." J Bacteriol 113(2);687-96. PMID: 4632320

BRENDA, 2014: BRENDA team (2014). "Imported from BRENDA version existing on Aug 2014." http://www.brenda-enzymes.org.

Caballero83: Caballero E, Baldoma L, Ros J, Boronat A, Aguilar J (1983). "Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli." J Biol Chem 1983;258(12);7788-92. PMID: 6345530

Cabiscol90: Cabiscol E, Hidalgo E, Badia J, Baldoma L, Ros J, Aguilar J (1990). "Oxygen regulation of L-1,2-propanediol oxidoreductase activity in Escherichia coli." J Bacteriol 172(9);5514-5. PMID: 2203757

Cabiscol92: Cabiscol E, Badia J, Baldoma L, Hidalgo E, Aguilar J, Ros J (1992). "Inactivation of propanediol oxidoreductase of Escherichia coli by metal-catalyzed oxidation." Biochim Biophys Acta 1118(2);155-60. PMID: 1730033

Cabiscol94: Cabiscol E, Aguilar J, Ros J (1994). "Metal-catalyzed oxidation of Fe2+ dehydrogenases. Consensus target sequence between propanediol oxidoreductase of Escherichia coli and alcohol dehydrogenase II of Zymomonas mobilis." J Biol Chem 269(9);6592-7. PMID: 8120011

Cameron86: Cameron, D.C., Cooney, C.L. (1986). "A novel fermentation: the production of (R)-1,2-propanediol and acetol by Clostridium thermosaccharolyticum." Nature Bio/Technology 4:651-654.

Chang04: Chang DE, Smalley DJ, Tucker DL, Leatham MP, Norris WE, Stevenson SJ, Anderson AB, Grissom JE, Laux DC, Cohen PS, Conway T (2004). "Carbon nutrition of Escherichia coli in the mouse intestine." Proc Natl Acad Sci U S A 101(19);7427-32. PMID: 15123798

Chen83: Chen YM, Lin EC, Ros J, Aguilar J (1983). "Use of operon fusions to examine the regulation of the L-1,2-propanediol oxidoreductase gene of the fucose system in Escherichia coli K12." J Gen Microbiol 129(11);3355-62. PMID: 6319547

Chen84: Chen YM, Lin EC (1984). "Post-transcriptional control of L-1,2-propanediol oxidoreductase in the L-fucose pathway of Escherichia coli K-12." J Bacteriol 157(1);341-4. PMID: 6418721

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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