Note: a dashed line (without arrowheads) between two compound names is meant to imply that the two names are just different instantiations of the same compound -- i.e. one may be a specific name and the other a general name, or they may both represent the same compound in different stages of a polymerization-type pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655
Expected Taxonomic Range:
chorismate is the principal common precursor of the aromatic amino acids L-tryptophan, L-tyrosine and L-phenylalanine, as well as the essential compounds tetrahydropteroyl mono-L-glutamate, ubiquinone-8, menaquinol-8 and enterobactin (enterochelin). The pathway from D-erythrose 4-phosphate to chorismate is known as the common pathway, or shikimate pathway. A review of the elucidation of the common pathway and its terminal pathway branches to the aromatic amino acids can be found in Pittard, J. and J. Yang (2008) "Biosynthesis of the Aromatic Aminio Acids." EcoSal 18.104.22.168 [ECOSAL].
Subpathways: ubiquinol-8 biosynthesis (prokaryotic) , octaprenyl diphosphate biosynthesis , superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis , superpathway of ubiquinol-8 biosynthesis (prokaryotic) , enterobactin biosynthesis , menaquinol-8 biosynthesis , demethylmenaquinol-8 biosynthesis I , 1,4-dihydroxy-2-naphthoate biosynthesis I , superpathway of tetrahydrofolate biosynthesis , tetrahydrofolate biosynthesis , 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I , 4-aminobenzoate biosynthesis , 2,3-dihydroxybenzoate biosynthesis , tryptophan biosynthesis , phenylalanine biosynthesis I , tyrosine biosynthesis I , chorismate biosynthesis I , chorismate biosynthesis from 3-dehydroquinate , 3-dehydroquinate biosynthesis I
Unification Links: EcoCyc:ALL-CHORISMATE-PWY
Achari97: Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK (1997). "Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase." Nat Struct Biol 4(6);490-7. PMID: 9187658
Adachi08: Adachi O, Ano Y, Toyama H, Matsushita K (2008). "A novel 3-dehydroquinate dehydratase catalyzing extracellular formation of 3-dehydroshikimate by oxidative fermentation of Gluconobacter oxydans IFO 3244." Biosci Biotechnol Biochem 72(6);1475-82. PMID: 18540103
Adachi74: Adachi O, Kohn LD, Miles EW (1974). "Crystalline alpha2 beta2 complexes of tryptophan synthetase of Escherichia coli. A comparison between the native complex and the reconstituted complex." J Biol Chem 249(24);7756-63. PMID: 4609974
Adams14: Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT (2014). "Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species." MBio 5(4). PMID: 25006229
Akanuma05: Akanuma S, Miyagawa H, Kitamura K, Yamagishi A (2005). "A detailed unfolding pathway of a (beta/alpha)8-barrel protein as studied by molecular dynamics simulations." Proteins 58(3);538-46. PMID: 15614829
Akhtar08: Akhtar TA, McQuinn RP, Naponelli V, Gregory JF, Giovannoni JJ, Hanson AD (2008). "Tomato gamma-glutamylhydrolases: expression, characterization, and evidence for heterodimer formation." Plant Physiol 148(2);775-85. PMID: 18757550
Akowski97: Akowski JP, Bauerle R (1997). "Steady-state kinetics and inhibitor binding of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tryptophan sensitive) from Escherichia coli." Biochemistry 1997;36(50);15817-22. PMID: 9398312
Al12: Al Mamun AA, Lombardo MJ, Shee C, Lisewski AM, Gonzalez C, Lin D, Nehring RB, Saint-Ruf C, Gibson JL, Frisch RL, Lichtarge O, Hastings PJ, Rosenberg SM (2012). "Identity and function of a large gene network underlying mutagenic repair of DNA breaks." Science 338(6112);1344-8. PMID: 23224554
Almo94: Almo SC, Smith DL, Danishefsky AT, Ringe D (1994). "The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli." Protein Eng 7(3);405-12. PMID: 7909946
Anderson11: Anderson DD, Quintero CM, Stover PJ (2011). "Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria." Proc Natl Acad Sci U S A 108(37);15163-8. PMID: 21876188
Anderson88c: Anderson KS, Sikorski JA, Johnson KA (1988). "Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements." Biochemistry 1988;27(5);1604-10. PMID: 3284585
Anderson91: Anderson KS, Kati WM, Ye Q-Z, Liu J, Walsh CT, Benesi AJ (1991). "Isolation and structure elucidation of the 4-amino-4-deoxychorismate intermediate in the PABA enzymatic pathway." J. Am. Chem. Soc. 113, 3198-3200.
Andreotti94: Andreotti G, Tutino ML, Sannia G, Marino G, Cubellis MV (1994). "Indole-3-glycerol-phosphate synthase from Sulfolobus solfataricus as a model for studying thermostable TIM-barrel enzymes." Biochim Biophys Acta 1208(2);310-5. PMID: 7947963
Appleman90: Appleman JR, Howell EE, Kraut J, Blakley RL (1990). "Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH." J Biol Chem 1990;265(10);5579-84. PMID: 2108144
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