MetaCyc Enzyme: arginase

Gene: rocF Accession Number: G-288 (MetaCyc)

Species: Bacillus subtilis

Molecular Weight of Polypeptide: 32.154 kD (from nucleotide sequence) [Bairoch93a ]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Enzymatic reaction of: arginase

Synonyms: arginine amidinase, canavanase, L-arginine amidinohydrolase

EC Number:

L-arginine + H2O <=> urea + L-ornithine

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

In Pathways: L-arginine degradation I (arginase pathway)

Arginase catalyzes the first reaction in the arginine catabolic pathway also known as the arginase pathway. [BSUB93, Gardan97, Gardan95]

Cofactors or Prosthetic Groups: Mn2+ [Comment 1]

Inhibitors (Competitive): L-ornithine [BSUB93]

Primary Physiological Regulators of Enzyme Activity: L-ornithine


Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

BSUB93: "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." (1993). Editors: Sonenshein, A.L., Hoch, J.A., Losick, R. American Society For Microbiology, Washington, DC.

Gardan95: Gardan R, Rapoport G, Debarbouille M (1995). "Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis." J Mol Biol 1995;249(5);843-56. PMID: 7540694

Gardan97: Gardan R, Rapoport G, Debarbouille M (1997). "Role of the transcriptional activator RocR in the arginine-degradation pathway of Bacillus subtilis." Mol Microbiol 1997;24(4);825-37. PMID: 9194709

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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