Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: arginase

Gene: rocF Accession Number: G-288 (MetaCyc)

Species: Bacillus subtilis

Molecular Weight of Polypeptide: 32.154 kD (from nucleotide sequence) [Bairoch93a ]

Gene-Reaction Schematic: ?


Enzymatic reaction of: arginase

Synonyms: arginine amidinase, canavanase, L-arginine amidinohydrolase

EC Number: 3.5.3.1

L-arginine + H2O <=> urea + L-ornithine

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

In Pathways: arginine degradation I (arginase pathway)

Summary:
Arginase catalyzes the first reaction in the arginine catabolic pathway also known as the arginase pathway. [Editors93, Gardan97, Gardan95]

Cofactors or Prosthetic Groups: Mn2+ [Comment 1]

Inhibitors (Competitive): L-ornithine [Editors93]

Primary Physiological Regulators of Enzyme Activity: L-ornithine


References

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Editors93: Editors: Abraham L. Sonenshein, James A. Hoch, Richard Losick (1993). "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." American Society For Microbiology, Washington, DC 20005.

Gardan95: Gardan R, Rapoport G, Debarbouille M (1995). "Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis." J Mol Biol 1995;249(5);843-56. PMID: 7540694

Gardan97: Gardan R, Rapoport G, Debarbouille M (1997). "Role of the transcriptional activator RocR in the arginine-degradation pathway of Bacillus subtilis." Mol Microbiol 1997;24(4);825-37. PMID: 9194709


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC13B.