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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: trehalose synthase

Gene: treS Accession Number: G-4281 (MetaCyc)

Synonyms: MTSase

Species: Pimelobacter sp. R48

Summary:
The trehalose synthase from Pimelobacter sp. R48 is the first enzyme that catalyzes the conversion of maltose to trehalose to be isolated. The purified enzyme converted maltose into trehalose and trehalose into maltose, and released a small amount of glucose from both substrates. It was inactive with all other saccharides tested. The equilibrium of this reaction lied far in the direction of trehalose synthesis.

Gene Citations: [Tsusaki96]

Molecular Weight of Polypeptide: 62 kD (experimental) [Nishimoto96 ]

pI: 4.6 [Nishimoto96]

Unification Links: Protein Model Portal:P72235 , UniProt:P72235

Relationship Links: CAZy:IN-FAMILY:GH13 , Entrez-Nucleotide:PART-OF:D78198 , InterPro:IN-FAMILY:IPR006047 , InterPro:IN-FAMILY:IPR006589 , InterPro:IN-FAMILY:IPR012810 , InterPro:IN-FAMILY:IPR013780 , InterPro:IN-FAMILY:IPR013781 , InterPro:IN-FAMILY:IPR015902 , InterPro:IN-FAMILY:IPR017853 , Panther:IN-FAMILY:PTHR10357 , Pfam:IN-FAMILY:PF00128 , Smart:IN-FAMILY:SM00642

Gene-Reaction Schematic: ?

MultiFun Terms: metabolism biosynthesis of building blocks


Enzymatic reaction of: trehalose synthase

EC Number: 5.4.99.16

maltose <=> α,α-trehalose

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction of enzyme catalysis.

This reaction is reversible.

In Pathways: trehalose biosynthesis IV

Inhibitors (Unknown Mechanism): Cu2+ [Nishimoto96] , Hg2+ [Nishimoto96] , Ni2+ [Nishimoto96] , Zn2+ [Nishimoto96]

T(opt): 20 °C [Nishimoto96]

pH(opt): 7.5 [Nishimoto96]


References

Nishimoto96: Nishimoto T, Nakano M, Nakada T, Chaen H, Fukuda S, Sugimoto T, Kurimoto M, Tsujisaka Y (1996). "Purification and properties of a novel enzyme, trehalose synthase, from Pimelobacter sp. R48." Biosci Biotechnol Biochem 60(4);640-4. PMID: 8829531

Tsusaki96: Tsusaki K, Nishimoto T, Nakada T, Kubota M, Chaen H, Sugimoto T, Kurimoto M (1996). "Cloning and sequencing of trehalose synthase gene from Pimelobacter sp. R48." Biochim Biophys Acta 1290(1);1-3. PMID: 8645698


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC13B.